帕金森病是好发于中老年人的神经退行性疾病。目前治疗帕金森病的常用药物是左旋多巴，但是患者在服用几年之后会出现一系列的不良反应。姜黄素是一种提取自姜黄科、天南星科等植物中的疏水性多酚类成分，在帕金森病的研究和治疗中展现出潜在的疗效。研究表明，姜黄素可以通过保护多巴胺能神经元、抗炎、抗氧化、抗细胞凋亡、抗线粒体损伤、调节自噬等多种途径在帕金森病中发挥神经保护作用。总结了姜黄素在帕金森病治疗中涉及到的不同作用机制，为进一步开发安全可靠的药物提供参考。

Parkinson's disease is a common neurodegenerative disease,which often occurs in the middle-aged and elderly.At present,the commonly used drug for the treatment of Parkinson's disease is levodopa,but patients will experience a series of adverse reactions after taking it for several years.Curcumin is a kind of hydrophobic polyphenols from plants such as Curcuminaceae and Araceae,which shows potential curative effect in the research and treatment of Parkinson's disease.Studies have shown that curcumin can play a neuroprotective role in Parkinson's disease by protecting dopaminergic neurons,anti-inflammatory,anti-oxidation,anti-apoptotic,anti-mitochondrial damage,and regulating autophagy and other pathways.This paper summarizes different mechanisms of curcumin in treatment of Parkinson's disease,and provides a reference for the development of safe and reliable drugs in the future.

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上海市中央引导地方科技发展资金项目(YDZX20213100001002)