目的 探讨龙掌口含液联合丁硼乳膏治疗牙周炎的临床疗效。方法 选择2020年4月—2021年4月在沧州市人民医院诊治的86牙周炎患者，根据用药的差别分为对照组和治疗组，每组各43例。对照组给予丁硼乳膏，1 g/次涂抹于患处，5 min后清水漱口，4次/d。在此基础上，治疗组含漱龙掌口含液，10 mL/次，含漱2 min/次，4次/d。两组患者连续治疗7 d。观察两组患者临床疗效，比较治疗前后两组患者牙周指标牙周袋深度（PD）、龈沟出血指数（SBI）、菌斑指数（PLI）、牙龈指数（GI）和附着丧失（AL），SESS、Barthel、VAS和GOHAI评分，龈沟液细胞因子超敏-C反应蛋白（hs-CRP）、可溶性细胞间黏附分子-1（sICAM-1）、高迁移率族蛋白B1（HMGB1）、前列素E₂（PGE₂）和白细胞介素-23（IL-23）水平。结果 治疗后，对照组临床总有效率为81.40%，明显低于治疗组（97.67%，P＜0.05）。经治疗，两组PD、SBI、PLI、GI、AL均明显降低（P＜0.05），并以治疗组下降最为明显（P＜0.05）。治疗后，两组患者SESS评分和Barthel评分明显升高，而VAS评分和GOHAI均明显下降（P＜0.05），并以治疗组评分改善的最为明显（P＜0.05）。经治疗，两组患者龈沟液中hs-CRP、sICAM-1、HMGB1、PGE₂、IL-23水平均明显降低（P＜0.05），并以治疗组患者下降最为明显（P＜0.05）。结论 龙掌口含液联合丁硼乳膏治疗牙周炎可有效提高口腔自我效能，利于牙周状态改善，降低局部炎症反应。

Objective To investigate the clinical effect of Longzhang Oral Fluid combined with Dingpeng Emulsion in treatment of periodontitis.Methods Patients (86 cases) with periodontitis in Cangzhou People's Hospital from April 2020 to April 2021 were divided into control and treatment group by differences in medication,and each group had 43 cases.Patients in the control group were administered with Dingpeng Emulsion on the affected area,1 g/time,rinsed mouth with water after 5 min,four times daily.Patients in the treatment group were administered with Longzhang Oral Fluid on the basis of the control group,10 mL/time for 2 min,four times daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluation was evaluated,the periodontal indexes PD,SBI,PLI,GI,and AL,the scores of related scales SESS,Barthel,VAS,and GOHAI,the levels of cytokines hs-CRP,sICAM-1,HMGB1,PGE₂,and IL-23 in gingival crevicular fluid in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the control group was 81.40%,which was significantly lower than that of the treatment group (97.67%,P<0.05).After treatment,the indexes of PD,SBI,PLI,GI,and AL were significantly decreased in two groups (P<0.05),especially in the treatment group (P<0.05).After treatment,the SESS score and Barthel score were significantly increased,while the VAS score and GOHAI were significantly decreased in two groups (P<0.05),and these scores in the treatment group were significantly better than those in the control group (P<0.05).After treatment,the levels of hs-CRP,sICAM-1,HMGB1,PGE₂,and IL-23 in gingival crevicular fluid were significantly decreased in two groups (P<0.05),especially in the treatment group (P<0.05).Conclusion Longzhang Oral Fluid combined with Dingpeng Emulsion in the treatment of periodontitis can effectively improve oral self-efficacy,improve periodontal status and reduce local inflammatory reaction,which has good clinical application value.

R988.2

沧州市重点研发计划指导项目(172302016)