目的 探讨散风通窍滴丸联合布地奈德鼻喷雾剂治疗慢性单纯性鼻炎的临床疗效。方法 选取2020年1月—2022年1月天津市第四中心医院收治180例慢性单纯性鼻炎患者，随机分对照组（90例）和治疗组（90例）。对照组鼻吸入布地奈德鼻喷雾剂，每个鼻孔2喷，早晚各1次。在对照组的基础上，治疗组口服散风通窍滴丸，20丸/次，3次/d。两组用药7 d。观察两组患者临床疗效，比较治疗前后两组患者症状缓解时间，嗅觉障碍评分，血清因子γ干扰素（IFN-γ）、白细胞介素-4（IL-4）、肿瘤坏死因子-α（TNF-α）和白细胞介素-17（IL-17）水平，及不良反应情况。结果 治疗后，治疗组临床有效率（97.78%）明显高于对照组（86.67%，P＜0.05）。治疗后，治疗组鼻塞、打喷嚏、清鼻涕、嗅觉减低等好转时间均早于对照组（P＜0.05）。治疗后，两组患者嗅觉障碍中气味阈值、气味识别、气味鉴别评分明显升高（P＜0.05）；且治疗后，治疗组改善优于对照组（P＜0.05）。治疗后，两组血清因子IL-4、IL-17、TNF-α水平均明显下降，而IFN-γ明显升高（P＜0.05）；且治疗后血清因子水平改善优于对照组（P＜0.05）。治疗组不良发生率（6.67%）明显低于对照组（14.44%，P＜0.05）。结论 散风通窍滴丸联合布地奈德鼻喷雾剂治疗慢性单纯性鼻炎效果确切，能加快患者鼻塞等症状的改善，有效降低炎性因子，嗅觉功能恢复快。

Objective To investigate the clinical effect of Sanfeng Tongqiao Drop Pills combined with budesonide in treatment of chronic simple rhinitis.Methods Patients (180 cases) with chronic simple rhinitis in Tianjin Fourth Central Hospital from January 2020 to January 2022 were randomly divided into control (90 cases) and treatment (90 cases) group.Patients in the control group were administered with Budesonide Nasal Spray,2 sprays for each nostril,once in the morning and evening respectively.Patients in the treatment group were po administered with Sanfeng Tongqiao Drop Pills on the basis of the control group,20 pills/time,three times daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluation was evaluated,the relief time of symptom,the scores of olfactory disorder,the levels of serum factor IL-4,IL-17,TNF-α and IFN-γ,adverse reactions in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group (97.78%) was significantly higher than that of the control group (86.67%,P treatment of chronic simple rhinitis,which can accelerate the improvement of symptoms such as nasal congestion,effectively reduce inflammatory factors and restore olfactory function quickly.<0.05).After treatment,the improvement time of nasal congestion,sneezing,clear nose and decreased sense of smell in the treatment group was earlier than that in the control group (P<0.05).After treatment,the scores of odor threshold,odor recognition and odor discrimination in olfactory disorders in the two groups were significantly increased (P<0.05).After treatment,the improvement of the treatment group was better than that of the control group (P<0.05).After treatment,the levels of serum factors IL-4,IL-17 and TNF-α in the two groups were significantly decreased,while IFN-γ was significantly increased (P<0.05).The improvement of serum factor level after treatment was better than that of the control group (P<0.05).The incidence of adverse events in the treatment group (6.67%) was significantly lower than that in the control group (14.44%,P<0.05).Conclusion Sanfeng Tongqiao Drop Pills combined with Budesonide Nasal Spray is effective in the

R987

天津市卫生健康委科技项目资助项目(ZC20163)