目的 探讨欧龙马滴剂联合阿莫西林克拉维酸钾治疗儿童急性分泌性中耳炎的临床疗效。方法 选择2019年1月—2021年12月平煤神马医疗集团总医院收治的120例急性分泌性中耳炎患儿，随机分对照组和治疗组，每组各60例。对照组口服阿莫西林克拉维酸钾干混悬剂，每次25 mg/kg，2次/d。在对照组的基础上，治疗组口服欧龙马口服滴剂，3.5 mL/次，3次/d。两组连续用药10 d。观察两组患者临床疗效，比较治疗前后两组患者症状缓解时间，听力改善情况，血清因子白细胞介素-1β（IL-1β）、降钙素原（PCT）、白细胞介素-8（IL-8）和血小板活化因子（PAF）水平，及不良反应。结果 治疗后，治疗组临床有效率（98.33%）明显高于对照组（83.33%，P＜0.05）。治疗后，治疗组症状缓解时间均早于对照组（P＜0.05）。治疗后，两组患儿听力均明显改善（P＜0.05），且治疗组患儿的听力改善情况好于对照组（P＜0.05）。治疗后，两组血清因子IL-1β、IL-8、PCT、PAF水平明显下降（P＜0.05），且治疗组明显低于对照组（P＜0.05）。治疗组不良反应发生率（6.67%）明显低于对照组（15.01%，P＜0.05）。结论 欧龙马滴剂联合阿莫西林克拉维酸钾治疗儿童急性分泌性中耳炎效果确切，有效缩短了症状缓解时间，听力恢复明显。

Objective To investigate the clinical study of Sinupret Drops combined with amoxicillin and clavulanate potassium in treatment of acute secretory otitis media in children.Methods Children (120 cases) with acute secretory otitis media in General Hospital of Pingmei Shenma Group from January 2019 to December 2021 were randomly divided into control and treatment group,and each group had 60 cases.Children in the control group po were administered with Amoxicillin and Clavulanate Potassium for Suspension,25 mg/kg every time,twice daily.Children in the treatment group were po administered with Sinupret Drops on the basis of the control group,3.5 mL/time,three times daily.Children in two groups were treated for 10 d.After treatment,the clinical evaluation was evaluated,the relief time of symptom,the improvement of hearing,the levels of serum factor IL-1β,IL-8,PCT,PAF,and adverse reaction in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group (98.33%) was significantly higher than that of the control group (83.33%,P<0.05).After treatment,the relief time of symptom in the treatment group was earlier than that in the control group (P<0.05).After treatment,the hearing in two groups was significantly improved (P<0.05),and the hearing improvement in the treatment group was better than that of the control group (P<0.05).After treatment,the levels of serum factors IL-1β,IL-8,PCT,and PAF in two groups were significantly decreased (P<0.05),and those in the treatment group were significantly lower than those in the control group (P<0.05).The incidence of adverse reactions in the treatment group (6.67%) was significantly lower than that in the control group (15.01%,P<0.05).Conclusion Sinupret Drops combined with amoxicillin and clavulanate potassium have definite therapeutic effects in treatment of acute secretory otitis media in children,effectively shortens the relief time of symptom,the recovery of hearing is obvious.

R987

中国平煤神马能源化工集团有限责任公司科研项目(4104022021180708)