目的 观察菖麻熄风片联合氟哌啶醇片治疗小儿抽动秽语综合征的临床疗效。方法 选取2019年8月—2021年6月河南科技大学第一附属医院接收的96例抽动秽语综合征患儿，根据入院奇偶顺序将患儿分为对照组和治疗组，每组各48例。对照组患儿口服氟哌啶醇片，初始剂量0.03 mg/(kg·d)，每10天增加0.025～0.050 mg/(kg·d)，最高剂量不超过0.15 mg/(kg·d)。治疗组患儿在对照组治疗基础上口服菖麻熄风片，5～6岁，1片/次，3次/d；7～12岁，2片/次，3次/d。两组患儿连续治疗4周。观察两组的临床疗效，比较两组的智力发育情况、疗效、脑电图（EEG）情况、耶鲁综合抽动严重程度量表（YGTSS）评分、血清神经递质水平。结果 治疗后，治疗组的总有效率为93.75%，高于对照组的总有效率70.83%，差异有统计学意义（P＜0.05）。治疗后，两组运动性抽动、发生性抽动评分均较治疗前下降（P＜0.05），且治疗组运动性抽动、发生性抽动评分低于对照组（P＜0.05）。治疗后，两组操作智商、言语智商、总智商评分均较治疗前升高（P＜0.05），且治疗组操作智商、言语智商、总智商评分高于对照组（P＜0.05）。治疗后，治疗组EEG正常例数明显多于对照组（P＜0.05）。治疗后，两组血清多巴胺（DA）、5-羟色胺（5-HT）、去甲肾上腺素（NE）水平均较治疗前降低（P＜0.05），且治疗组血清DA、5-HT、NE水平低于对照组（P＜0.05）。结论 菖麻熄风片联合氟哌啶醇片治疗小儿抽动秽语综合征的疗效显著，可有效改善患儿临床症状、智力发育和EEG情况，调节血清神经递质DA、NE、5-HT水平。

Objective To observe the clinical efficacy of Changma Xifeng Tablets combined with Haloperidol Tablets in treatment of Tourette's syndrome in children.Methods Children (96 cases) with Tourette's syndrome in the First Affiliated Hospital of Henan University of Science and Technology from August 2019 to June 2021 were divided into control and treatment groups according to the parity order of admission,and each group had 48 cases.Patients in the control group were po administered with Haloperidol Tablets,the initial dose is 0.03 mg/(kg·d),with an increase of 0.025-0.050 mg/(kg·d) every 10 d,and the maximum dose does not exceed 0.15 mg/(kg·d).Patients in the treatment group were po administered with Changma Xifeng Tablets on the basis of the control group,5-6 years old,1 tablet/time,three times daily,7-12 years old,2 tablets/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies were evaluated,and the intelligence development,curative effect,EEG,YGTSS score,and serum neurotransmitter level in two groups were compared.Results After treatment,the total effective rate of the treatment group was 93.75%,higher than that of the control group of 70.83%,and the difference was statistically significant (P<0.05).After treatment,the scores of locomotor twitch and paroxysmal twitch in two groups were decreased compared with those before treatment (P<0.05),and the scores of locomotor twitch and paroxysmal twitch in the treatment group were lower than those in the control group (P<0.05).After treatment,the scores of operational IQ,verbal IQ,and total IQ in two groups were higher than those before treatment (P<0.05),and the scores of operational IQ,verbal IQ,and total IQ in the treatment group were higher than those in the control group (P<0.05).After treatment,the EEG normal cases in the treatment group were significantly better than those in the control group (P<0.05).After treatment,the serum levels of DA,5-HT,and NE in two groups were lower than those before treatment (P<0.05),and the serum levels of DA,5-HT,and NE in the treatment group were lower than those in the control group (P<0.05).Conclusion Changma Xifeng Tablets combined with Haloperidol Tablets has clinical curative effect in treatment of Tourette's syndrome in children,can effectively improve the clinical symptoms,intellectual development and EEG of children,and regulate the serum levels of neurotransmitters DA,NE,and 5-HT.

R985

河南省科技发展计划项目(182102320764)