目的 探讨解毒生肌膏联合康复新液雾化和臭氧水冲洗治疗肛周脓肿的临床疗效。方法 选取2020年1月—2021年11月保定市第五医院收治的100例肛周脓肿患者，随机分为对照组（50例）和治疗组（50例）。对照组采用康复新液雾化联合臭氧水冲洗方案，首先将康复新液放入医用超声雾化机中，熏洗30 min，2次/d；然后臭氧水（浓度≥4.3 mg/L）对创面持续冲洗5 min，2次/d。治疗组在对照组的基础上，于患处涂敷解毒生肌膏，2次/d。两组患者连续治疗4周。观察两组患者临床疗效，比较治疗前后两组患者疼痛及体征情况，创面愈合情况，血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、高敏-C反应蛋白（hs-CRP）、转化生长因子-β（TGF-β）和表皮细胞生长因子（EGF）水平。结果 治疗后，治疗组临床总有效率显著高于对照组（98.00% vs 84.00%，P＜0.05）。治疗后，两组视觉疼痛评分（VAS）、创面水肿、肉芽组织和分泌物评分比治疗前均明显下降（P＜0.05），且治疗组显著低于对照组（P＜0.05）。治疗后，治疗组创面愈合时间、水肿缓解时间和出血缓解时间显著短于对照组（P＜0.05）。治疗后，两组患者IL-6、TNF-α和hs-CRP水平较治疗前显著降低，而TGF-β和EGF水平显著升高（P＜0.05），且治疗组IL-6、TNF-α、hs-CRP、TGF-β和EGF水平明显好于对照组（P＜0.05）。结论 解毒生肌膏联合康复新液雾化和臭氧水冲洗治疗肛周脓肿效果确切，明显减轻患者疼痛、水肿和分泌物，降低炎症反应，加速创面愈合和促进患者恢复。

Objective To investigate the clinical effect of Jiedu Shengji Ointment combined with Kangfuxin Liquid atomization and ozone water flushing in treatment of perianal abscess.Methods Patients (100 cases) with perianal abscess in NO.5 Hospital of Baoding from January 2020 to November 2021 were randomly divided into control (50 cases) and treatment (50 cases) group.Patients in the control group were administered with the scheme of atomization of Kangfuxin Liquid combined with ozone water,firstly,Kangfuxin Liquid was put into the medical ultrasonic atomizer and fumigated for 30 min,twice daily,then the wound was washed continuously with ozone water (concentration ≥ 4.3 mg/L) for 5 min,twice daily.Patients in the treatment group were administered with Jiedu Shengji Ointment to the affected area on the basis of the control group,twice daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical evaluation was evaluated,the pain and signs,wound healing,inflammatory factors,the levels of IL-6,TNF-α,hs-CRP,TGF-β,and EGF in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was significantly higher than that of the control group (98.00%vs 84.00%,P<0.05).After treatment,the scores of VAS pain,wound edema,granulation tissue,and secretion in two groups were significantly lower than those before treatment (P<0.05),and which in the treatment group were significantly lower than those in the control group (P<0.05).After treatment,the wound healing time,edema relief time,and bleeding relief time in the treatment group were significantly shorter than those in the control group (P<0.05).After treatment,the levels of IL-6,TNF-α,and hs-CRP were significantly decreased,while the levels of TGF-β,and EGF were significantly increased in both groups (P<0.05),and the levels of IL-6,TNF-α,hs-CRP,TGF-β,and EGF in the treatment group were significantly better than those in the control group (P<0.05).Conclusion Jiedu Shengji Ointment combined with Kangfuxin Liquid atomization and ozone water flushing is effective in the treatment of perianal abscess,which can significantly reduce pain,edema and secretion,reduce inflammatory reaction,accelerate wound healing and promote patient recovery.

R986

保定市科技计划项目(2141ZF226)