目的 探讨肤痒颗粒联合阿伐斯汀治疗慢性荨麻疹的临床疗效。方法 选择2019年1月—2021年3月资阳市第一人民医院收治的82例慢性荨麻疹患者，按随机数字表法分为对照组（41例）和治疗组（41例）。对照组口服阿伐斯汀胶囊，8 mg/次，2次/d。治疗组在对照组基础上口服肤痒颗粒，2袋/次，3次/d。两组患者治疗7 d。观察两组患者临床疗效，比较治疗前后两组患者症状缓解时间，生活质量指数（DLQI）评分，血清肿瘤坏死因子-α（TNF-α）、可溶性黏附因子-1（sVCAM-1）、白细胞介素-4（IL-4）和γ干扰素（INF-γ）水平及不良反应情况。结果 治疗组总有效率（97.56%）明显高于对照组（78.05%，P＜0.05）。治疗后，治疗组皮肤瘙痒、皮疹、胸闷、心悸缓解时间均明显早于对照组（P＜0.05）。治疗后，两组患者DLQI评分均明显下降（P＜0.05），且治疗组明显低于对照组（P＜0.05）。治疗后，两组患者血清因子IL-4、TNF-α和sVCAM-1水平明显降低，而INF-γ水平明显升高（P＜0.05），且治疗组血清因子水平明显好于对照组（P＜0.05）。治疗组不良反应发生率明显低于对照组（7.32% vs 17.07%，P＜0.05）。结论 肤痒颗粒联合阿伐斯汀治疗慢性荨麻疹效果确切，可有效改善临床症状，减弱机体炎性反应，且安全有效。

Objective To investigate the efficacy of Fuyang Granules combined with avastin in treatment of chronic urticaria.Methods Patients (82 cases) with chronic urticaria in First People's Hospital of Ziyang from January 2019 to March 2021 were divided into control (41 cases) and treatment (41 cases) group by random number table method.Patients in the control group were po administered with Acrivastine Capsules,8 mg/time,twice daily.Patients in the treatment group were po administered with Fuyang Granules on the basis of the control group,2 bags/time,three times daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluation was evaluated,the relief time of symptom,DLQI scores,the levels of serum factor IL-4,TNF-α,sVCAM-1 and INF-γ,adverse reactions in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group (97.56%) was significantly higher than that of the control group (78.05%,P<0.05).After treatment,the relief time of itchy skin,rash,chest tightness,palpitations in the treatment group was significantly earlier than that in the control group (P<0.05).After treatment,the DLQI score of the two groups were significantly decreased (P<0.05),and which in the treatment group was significantly lower than in the control group (P<0.05).After treatment,the serum levels of IL-4,TNF-α,and sVCAM-1 in two groups were significantly decreased,while the level of INF-γ were significantly increased (P<0.05),and the level of serum factors in the treatment group was significantly better than that in the control group (P<0.05).The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (7.32%vs 17.07%,P<0.05).Conclusion Fuyang Granule with avastin combined is effective in the treatment of chronic urticaria,which can effectively improve clinical symptoms and reduce inflammatory reaction,and it is safe and effective.

R986

资阳市科技计划项目(Zykjjsc20-2018-14)