目的 探讨铝镁加混悬液联合伏诺拉生治疗反流性食管炎的临床疗效。方法 选取2019年3月—2021年3月空军军医大学第二附属医院消化内科收治的120例反流性食管炎患者，按照随机数字表法将所有患者分为对照组和治疗组，每组各60例。对照组口服富马酸伏诺拉生片，20 mg/次，1次/d。治疗组在对照组基础上口服铝镁加混悬液，1袋/次，4次/d。两组用药7周。观察两组的治疗效果，比较两组症状缓解时间、血清胃激素水平、血清炎性因子水平。结果 治疗后，治疗组总有效率是98.33%，显著高于对照组的83.33%（P＜0.05）。治疗后，治疗组反酸、烧心、胸痛、嗳气等症状缓解时间均短于对照组（P＜0.05）。治疗后，两组胃蛋白酶I（PGI）、胃动素（GAS）、胃泌素（MOT）水平均较治疗前显著降低（P＜0.05）；治疗后，治疗组PGI、GAS、MOT水平均低于对照组（P＜0.05）。治疗后，两组白细胞介素-1β（IL-1β）、白细胞介素-2（IL-2）、肿瘤坏死因子-α（TNF-α）、白细胞介素-17（IL-17）水平均较治疗前显著降低（P＜0.05）；治疗后，治疗组血清学指标水平低于对照组（P＜0.05）。结论 铝镁加混悬液联合伏诺拉生治疗反流性食管炎效果确切，可较好地缓解相关临床症状，并能有效降低机体炎性反应，值得推广使用。

Objective To investigate the clinical study of Almagate Suspension combined with vonoprazan in treatment of reflux esophagitis.Methods A total of 120 patients with reflux esophagitis admitted to the Department of Gastroenterology of the Second Affiliated Hospital of Air Force Medical University from March 2019 to March 2021 were selected.All patients were divided into control group and treatment group according to the random number table method,with 60 cases in each group.Patients in the control group were po administered with Vonoprazan Fumarate Tablets,20 mg/time,once daily.Patients in the treatment group were po administered with Almagate Suspension on the basis of the control group,1 bag/time,4 times daily.Both groups were treated for 7 weeks.The treatment effect of the two groups was observed,and the symptom relief time,serum gastric hormone level and serum inflammatory factor level were compared between the two groups.Results After treatment,the total effective rate of the treatment group was 98.33%,which was significantly higher than 83.33% of the control group (P<0.05).After treatment,the remission time of acid regurgitation,heartburn,chest pain,belching and other symptoms in the treatment group were shorter than those in the control group (P<0.05).After treatment,the levels of pepsin I (PGI),motilin (GAS) and gastrin (MOT) in the two groups were significantly decreased compared with those before treatment (P<0.05).After treatment,the levels of PGI,GAS and MOT in the treatment group were lower than those in the control group (P<0.05).After treatment,the levels of interleukin-1β(IL-1β),interleukin-2(IL-2),tumor necrosis factor-α(TNF-α) and interleukin-17(IL-17) in the two groups were significantly decreased compared with those before treatment (P<0.05).After treatment,the serum level of the treatment group was lower than that of the control group (P <0.05).Conclusion Almagate Suspension combined with vonoprazan has exact effect in treatment of reflux esophagitis,and can relieve the related clinical symptoms and effectively reduce the inflammatory response of the body,which is worthy of popularization and use.

R975

陕西省科技惠民计划项目(2015HM-11)