目的 探讨丹参多酚酸联合尼麦角林治疗急性脑梗死恢复期的临床疗效。方法 选取2019年6月—2021年12月在中国人民解放军北部战区总医院治疗的72例急性脑梗死恢复期患者，随机将患者分为对照组和治疗组，每组各36例。对照组口服尼麦角林片，20 mg/次，3次/d。在对照组的基础上，治疗组静脉滴注注射用丹参多酚酸，0.13 g/次，加于生理盐水250 mL中，1次/d。两组连续治疗14 d。观察两组患者临床疗效，比较治疗前后两组患者症状改善时间，美国国立卫生研究院卒中量表（NIHSS）评分、日常生活活动能力（BI）评分，血清因子肿瘤坏死因子-α（TNF-α）、血管间黏附分子-1（VCAM-1）、白细胞介素-6（IL-6）和单核细胞趋势蛋白-1（MCP-1）水平，及不良反应情况。结果 治疗后，治疗组临床有效率（97.22%）明显高于对照组（75.00%，P＜0.05）。治疗后，治疗组症状改善时间均明显早于对照组（P＜0.05）。治疗后，两组BI评分明显升高，而NIHSS评分明显下降（P＜0.05），且治疗组BI和NIHSS评分明显好于对照组（P＜0.05）。治疗后，两组血清因子IL-6、VCAM-1、TNF-α、MCP-1水平明显降低（P＜0.05），且治疗组明显低于对照组（P＜0.05）。治疗组不良反应发生率（8.33%）明显低于对照组（19.44%，P＜0.05）。结论 丹参多酚酸联合尼麦角林治疗急性脑梗死恢复期疗效较好，可有效改善神经功能损伤，增强日常活动能力，并能降低炎性因子。

Objective To explore the treatment effect of salvianolic acid combined with nicergoline in treatment of acute cerebral infarction in convalescent period.Methods Patients (72 cases) with acute cerebral infarction in convalescent period in General Hospital of Northern Theater Command from June 2019 to December 2021 were randomly divided into control and treatment group,and each group had 36 cases.Patients in the control group were po administered with Nicergoline Tablets,20 mg/time,three times daily.Patients in the treatment group were iv administered with Salvianolic Acid for injection on the basis of the control group,0.13 g/time added into normal saline 250 mL,once daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluation was evaluated,the improvement time of symptom,the scores of BI and NIHSS,the levels of serological IL-6,VCAM-1,TNF-α and MCP-1,adverse reactions in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group (97.22%) was significantly higher than that of the control group (75.00%,P<0.05).After treatment,the improvement time of symptom in the treatment group was significantly earlier than that in the control group (P<0.05).After treatment,the BI score of the two groups was significantly increased,while the NIHSS score was significantly decreased (P<0.05),and the BI and NIHSS scores of the treatment group were significantly better than those of the control group (P<0.05).After treatment,the levels of serum factors IL-6,VCAM-1,TNF-α and MCP-1 in two groups were significantly decreased (P<0.05),and which in the treatment group were significantly lower than those in the control group (P<0.05).The incidence of adverse reactions in the treatment group (8.33%) was significantly lower than that in the control group (19.44%,P<0.05).Conclusion Salvianolic acid combined with nicergoline have good therapeutic effects in treatment of acute cerebral infarction in convalescent stage,which can effectively improve the injury of neurological function,enhance the ability of daily activity and reduce inflammatory factors.

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