目的 探讨消渴康颗粒联合聚乙二醇洛塞那肽注射液治疗2型糖尿病的临床疗效。方法 选取2020年2月—2022年1月在天津医科大学第二医院就诊的104例2型糖尿病患者，按照随机数字表法将所有患者分为对照组和治疗组，每组52例。对照组皮下注射聚乙二醇洛塞那肽注射液，0.1 mg/次，1次/周。治疗组在对照组基础上口服消渴康颗粒，1袋/次，3次/d。两组在治疗30 d后统计疗效。观察两组的临床疗效，比较两组血糖指标、血糖波动指标以及脂肪型脂肪酸结合蛋白（A-FABP）、趋化素（chemerin）、白细胞介素-17（IL-17）水平。结果 治疗后，治疗组的总有效率为96.15%，高于对照组的总有效率82.69%，组间比较差异显著（P<0.05）。治疗后，两组患者的空腹血糖（FPG）、糖化血红蛋白（HbA1c）、餐后2 h血糖（2 h BG）显著降低（P<0.05），治疗组FPG、HbA1c、2 h BG比对照组更低（P<0.05）。治疗后，两组的平均血糖波动幅度（MAGE）、日间血糖平均绝对差（MODD）、血糖水平标准差（SDBG）水平均明显降低（P<0.05），治疗组MAGE、MODD、SDBG水平明显低于对照组，组间差异有显著意义（P<0.05）。治疗后，两组的血清A-FABP、chemerin、IL-17水平均明显低于治疗前（P<0.05）；治疗组患者的血清A-FABP、chemerin、IL-17水平低于对照组，差异有统计学意义（P<0.05）。结论 消渴康颗粒联合聚乙二醇洛塞那肽注射液治疗2型糖尿病的疗效确切，可提高降糖疗效，降低血糖波动，调节A-FABP、chemerin、IL-17水平，值得临床推广运用。

Objective To investigate the clinical efficacy of Xiaokekang Granules combined with Polyethylene Glycol Loxenatide Injection in treatment of type 2 diabetes mellitus. Methods Patients (104 cases) with type 2 diabetes mellitus in the Second Hospital of Tianjin Medical University from February 2020 to January 2022 were randomly divided into control and treatment groups, and each group had 52 cases. Patients in the control group were sc administered with Polyethylene Glycol Loxenatide Injection, 0.1 mg/time, once weekly. Patients in the treatment group were po administered with Xiaokekang Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 30 d. After treatment, the clinical efficacies were evaluated, and the blood glucose indexes, the blood glucose fluctuation indexes, and the levels of A-FABP, chemerin, and IL-17 in two groups were compared. Results After treatment, the total effective rate of the treatment group was 96.15%, which was higher than 82.69% of the control group, and there was significant difference between two groups (P < 0.05). After treatment, the FPG, HbA1c, and 2 h BG in two groups were significantly decreased (P < 0.05), and the FPG, HbA1c and 2 h BG in the treatment group were lower than those in the control group (P < 0.05). After treatment, the levels of MAGE, MODD, and SDBG in two groups were significantly decreased (P < 0.05). The levels of MAGE, MODD, and SDBG in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the serum levels of A-FABP, chemerin, and IL-17 in two groups were significantly lower than those before treatment (P < 0.05). The serum levels of A-FABP, chemerin, and IL-17 in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Xiaokekang Granules combined with Polyethylene Glycol Loxenatide Injection has clinical curative effect in treatment of type 2 diabetes mellitus, which can improve the hypoglycemic effect, reduce the fluctuation of blood glucose, and adjust the levels of A-FABP, chemerin, and IL-17, it is worthy of clinical application.

R977

天津市教委科研计划项目（2020kj169）