目的 探讨丙卡特罗联合地塞米松磷酸钠治疗儿童支气管哮喘急性发作的临床研究。方法 选择2021年1月—2022年1月在南通市海门区人民医院诊疗的80例支气管哮喘急性发作患儿，随机分对照组（40例）和治疗组（40例）。对照组患儿静脉滴注地塞米松磷酸钠注射液，每次0.5 mg/kg，1次/d。治疗组在对照组的基础上口服盐酸丙卡特罗口服溶液，5 mL/次，2次/d。两组患儿连续治疗5 d。观察两组患儿临床疗效，比较治疗前后两组患儿症状好转时间，及血清白细胞介素-1β（IL-1β）、白细胞介素-17（IL-17）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）水平。结果 治疗后，治疗组临床有效率为97.50%，明显高于对照组77.50%（P<0.05）。治疗后，治疗组症状好转时间均明显早于对照组（P<0.05）。治疗后，两组患儿IL-1β、IL-17、TNF-α、CRP水平均明显降低，且治疗组明显均低于对照组（P<0.05）。结论 地塞米松磷酸钠联合盐酸丙卡特罗治疗支气管哮喘急性发作患儿效果明显，可有效改善支气管炎症反应，促进机体免疫力增加。

Objective To explore the clinical study of procaterol hydrochloride combined with dexamethasone sodium phosphate in treatment of acute exacerbation of bronchial asthma in children. Methods Children (80 cases) with acute exacerbation of bronchial asthma in Nantong Haimen People's Hospital from January 2021 to January 2022 were randomly divided into control (40 cases) and treatment (40 cases) group. Children in the control group were iv administered with Dexamethasone Sodium Phosphate Injection, 0.5 mg/kg at a time, once daily. Children in the treatment group were po administered with Procaterol Hydrochloride Oral Solution on the basis of the control group, 5 mL/time, twice daily. Children in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, the improvement time of symptoms, the levels of serological indexes IL-1β, IL-17, TNF-α, and CRP in two groups before and after treatment were compared. Results After treatment, the effective rate in the treatment group was higher than that in the control group (97.50% vs 77.50%, P < 0.05). After treatment, the improvement time of symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the levels of IL-1β, IL-17, TNF-α, CRP were significantly lower in the treatment group than which in the control group (P < 0.05). Conclusion The effect of Dexamethasone sodium phosphate combined with procaterol hydrochloride in treatment of acute exacerbation of bronchial asthma in children is obvious, which can effectively improve the reaction of bronchitis and promote the increase of body immunity.

R974