代谢相关脂肪性肝病既往称为非酒精性脂肪肝，与肥胖、糖尿病、高脂血症等关系密切，还明显增加心血管死亡的风险。大黄素是大黄、何首乌中主要的活性成分，具有多种生物学功能。大黄素可通过降低肝细胞脂质沉积、抑制肝脏炎症反应、抗胰岛素抵抗、抑制肝纤维化、抗氧化应激反应等多种途径对代谢相关脂肪性肝病发挥治疗作用。总结了大黄素治疗代谢相关脂肪性肝病的作用机制，为代谢相关脂肪性肝病的治疗提供参考。

Metabolic associated fatty liver disease (MAFLD), formerly known as non-alcoholic fatty liver disease, is closely related to obesity, diabetes, hyperlipidemia, etc., and also significantly increases the risk of cardiovascular death. Emodin is the main active ingredient in Rhei Radix et Rhizoma and Polygoni Multiflori Radix, and has a variety of biological functions. Emodin plays a therapeutic effects on MAFLD in multiple ways and multiple targets, such as reducing lipid deposition in liver cells, inhibiting hepatic inflammatory response, anti-insulin resistance, inhibiting liver fibrosis, and anti-oxidative stress response, etc. This paper discusses the mechanism of action of emodin in treatment of MAFLD, and provides a reference for the treatment of MAFLD.

R977

重庆市科卫联合医学科研项目(2018MSXM089)