目的 探讨京万红与重组人表皮生长因子凝胶联合治疗压力性损伤的临床疗效。方法 选择2019年1月—2021年12月在廊坊市中医医院治疗的120例皮损患者，随机分对照组和治疗组，每组各60例。对照组患者外用重组人表皮生长因子凝胶（酵母），生理盐水清洗创面后，取适量均匀涂于患处，1次/d。治疗组在对照组的基础上外用京万红软膏，生理盐水清理创面，将本品涂于消毒纱布上，敷盖创面，常规包扎，1次/d，1次/d。两组治疗30 d观察效果。观察两组患者临床疗效，比较治疗前后两组患者症状好转时间，血清白细胞介素-6（IL-6）、血清降钙素（PCT）、肿瘤坏死因子-α（TNF-α）和C反应蛋白（CRP）水平，及创面表皮生长因子（EGF）含量。结果 治疗后，治疗组临床有效率（98.33%）明显高于对照组（83.33%，P＜0.05）。治疗后，治疗组症状好转时间均早于对照组（P＜0.05），创面EGF含量明显高于对照组（P＜0.05）。治疗后，两组血清IL-6、PCT、TNF-α、CRP水平均明显降低（P＜0.05），且治疗组明显低于对照组（P＜0.05）。结论 重组人表皮生长因子凝胶与京万红软膏联合治疗效果满意，损伤皮肤改善明显，并能有效降低局部炎性反应。

Objective To investigate the efficacy of Jingwanhong combined with Recombinant Human Epidermal Growth Factor Gel in treatment of pressure injury. Methods Patients (120 cases) with pressure injury in Langfang Traditional Chinese Medicine Hospital from January 2019 to December 2021 were randomly divided into control and treatment group, and each had 60 cases. Patients in the control group were administered with Recombinant Human Epidermal Growth Factor Gel (Yeast), evenly apply proper amount to the affected area after washing the wound with normal saline, once daily. Patients in the treatment group were administered with Jingwanhong Ointment on the basis of the control group, normal saline for wound cleaning, and the product was applied to sterilized gauze for wound covering and conventional dressing, once daily, once daily. Patients in two groups were treated for 30 d. After treatment, the clinical evaluation was evaluated, the improvement time of symptom, the levels of IL-6, PCT, TNF-α and CRP, EGF content in wound in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (98.33%) was significantly higher than that of the control group (83.33%, P < 0.05). After treatment, the improvement time of symptoms in the treatment group was earlier than that in the control group (P < 0.05), and the content of EGF in the wound of the treatment group was significantly higher than that in the control group (P < 0.05). After treatment, the serum levels of IL-6, PCT, TNF-α and CRP in two groups were significantly decreased (P < 0.05), and those in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion The effect of Recombinant Human Epidermal Growth Factor Gel combined with Jingwanhong Ointment in treatment of pressure injury is satisfactory, the injured skin is improved obviously, and can effectively reduce the local inflammatory reaction.

R986

廊坊市科学技术课题支撑项目(2018013067)