目的 探讨消糜栓与氟康唑片联合治疗念珠菌性阴道炎的临床疗效。方法 选择2021年2月—2021年8月在濮阳市油田总医院治疗的97例念珠菌性阴道炎患者，随机分为对照组（49组）和治疗组（48组）。对照组患者口服氟康唑片，150 mg/次，1次/d。在对照组的基础上，治疗组阴道给予消糜栓，1粒/次，1次/d。两组用药7 d观察治疗效果。观察两组患者临床疗效，比较治疗前后两组患者症状改善时间，血清白细胞介素-6（IL-6）、γ干扰素（IFN-γ）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）水平，及不良反应情况。结果 治疗后，治疗组临床有效率为97.91%，明显高于对照组的81.63%（P＜0.05）。经治疗，治疗组症状改善时间均明显早于对照组（P＜0.05）。治疗后，两组患者血清IL-6、IFN-γ、TNF-α、CRP水平均明显降低（P＜0.05）；且治疗组IL-6、IFN-γ、TNF-α、CRP水平均明显低于对照组（P＜0.05）。治疗组不良反应发生率为6.25%，明显低于对照组的14.29%（P＜0.05）。结论 对于念珠菌性阴道炎治疗，采用氟康唑片与消糜栓治疗效果确切，并可以调节血清炎性因子水平，能有效降低复发率，且安全有效。

Objective To investigate the efficacy of Xiaomi Suppository combined with fluconazole in treatment of candidal vaginitis. Methods Patients (97 cases) with candidal vaginitis in Puyang Oilfield General Hospital from February 2021 to August 2021 were randomly divided into control (49 cases) and treatment (48 cases) group. Patients in the control group were po administered with Fluconazole Tablets, 150 mg/time, once daily. Patients in the treatment group were vaginally administered with Xiaomi Suppository on the basis of the control group, 1 grain/time, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, the improvement time of symptom, the levels of serum IL-6, IFN-γ, TNF-α and CRP, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.91%, significantly higher than 81.63% of the control group (P < 0.05). After treatment, the improvement time of symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the levels of serum IL-6, IFN-γ, TNF-α, CRP in two groups were significantly reduced (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). The incidence of adverse reactions in the treatment group was 6.25%, which was significantly lower than 14.29% in the control group (P < 0.05). Conclusion Fluconazole Tablets combined with Xiaomi Suppository is effective in the treatment of candidal vaginitis, which can regulate the level of serum inflammatory factors, effectively reduce the recurrence rate, and is safe and effective.

R984

河南省科学技术项目(9412011Y1064)