目的 分析南京医科大学附属脑科医院2019年1月—2021年12月执行国家组织药品集中采购政策后对抗精神病药物使用情况的影响。方法 采用回顾性研究方法对南京医科大学附属脑科医院2019年1月—2021年12月国家集采药品中抗精神病药物的用药品种、使用数量、使用金额、用药频度（DDDs）、日均费用（DDC）、排序比（B/A）、潜在节省费用等进行统计分析。结果 国家组织药品集中采购政策实施后，2021年较2020年第1批、第3批中选药品及同通用名药品使用数量分别增加了8.91%、14.73%，使用金额分别下降了13.99%、21.33%；DDDs最高的3位、DDC最低的3位均为国家集采中选品种；2021年第1批、第3批国家集采执行后潜在节省费用为470.43万元。结论 国家集采政策实施后，一定程度上解决了药品价格虚高的问题，切实降低了精神病患者的用药负担，提升了医保资金的使用效率。

Objective To analyze the effects of national centralized drug procurement policy on the use of antipsychotic drugs in The Affiliated Brain Hospital of Nanjing Medical University from January 2019 to December 2021. Methods A retrospective study was conducted to analyze the varieties, quantity, consumption sum, DDDs, DDC, B/A, and potential cost savings of antipsychotic drugs in national centralized drug collection from January 2019 to December 2021 in The Affiliated Brain Hospital of Nanjing Medical University. Results After the implementation of national centralized drug procurement policy, the number of selected drugs and drugs with the same generic name in 2021 increased by 8.91% and 14.73%, and the consumption sum decreased by 13.99% and 21.33%, respectively, compared with that in 2020. The 3 cultivars with the highest DDDs and the 3 cultivars with the lowest DDC were selected from the national collective collection. After the implementation of the first batch and the third batch of national collective production in 2021, the potential cost savings will be 470.43 million yuan. Conclusion After policy implement, some drug prices have returned to reasonable level so as to lower the drug expenditure of some patients and enhance the use effciency of medical insurance fund.

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