目的 选取2019—2021年安徽医科大学附属六安医院（六安市人民医院）质子泵抑制剂（PPIs）的使用情况进行分析和评价，以促进院内PPIs临床的合理使用。方法 调取2019—2021年安徽医科大学附属六安医院（六安市人民医院）PPIs的相关用药信息，对PPIs的销售金额、用药频度（DDDs）、限定日费用（DDC）和排序比（B/A）进行回顾性统计分析。结果 2019—2021年医院PPIs的用药金额总体呈下滑趋势，DDDs相对金额下降趋势偏缓，其中注射剂型的用药金额和DDDs近3年下降明显，而口服剂型DDDs相对较为平稳，药品价格有所下降。2019—2021年，由于药品价格下调，PPIs的DDC普遍呈下降趋势。DDC小于5万元的PPIs有雷贝拉唑钠肠溶片、兰索拉唑肠溶片及入围药品集中采购新增的3个品种。B/A>1的品种主要为口服剂型，而B/A<1的品种主要为注射剂型。结论 安徽医科大学附属六安医院（六安市人民医院）PPIs目录得到优化，使用渐趋合理，注射剂型PPIs给患者造成的经济负担较口服PPIs为重。在临床使用PPIs过程中，应优先选择口服PPIs，并兼顾疗效和成本，根据患者自身情况结合PPIs的药理药化特性选择合适的PPIs，提高PPIs的合理使用水平。

Objective The use of proton pump inhibitors (PPIs) in Lu'an Hospital of Anhui Medical University, Lu'an People's Hospital from 2019 to 2021 was analyzed and evaluated, in order to promote rational clinical use of PPIs in hospital. Methods The medication information related to PPIs in Lu'an Hospital of Anhui Medical University, Lu'an People's Hospital from 2019 to 2021 was collected, and the consumption sum, DDDs, DDC and B/A of PPIs were analyzed retrospectively. Results The overall consumption sum of PPIs in hospitals showed a downward trend from 2019 to 2021, while the relative consumption sum of DDDs showed a slow downward trend. Among them, the consumption sum and DDDs of injection dosage form decreased significantly in recent 3 years, while the DDDs of oral dosage form was relatively stable, and the drug price decreased. From 2019 to 2021, DDC of PPIs generally showed a downward trend due to the decrease in drug prices. PPIs with DDC less than 50 000 yuan include Rabeprazole Sodium Enteric-coated Tablets, Lansoprazole Enteric-coated Tablets and 3 newly added products of centralized procurement of shortlisted drugs. The varieties with B/A > 1 were mainly oral dosage form, while the varieties with B/A < 1 were mainly injection form. Conclusion The PPIs catalogue of Lu'an Hospital of Anhui Medical University, Lu'an People's Hospital has been optimized, the use of PPIs is becoming reasonable. Economic burden of injectable PPIs is heavier than that of oral PPIs. In the process of clinical use of PPIs, oral PPIs should be given priority, efficacy and cost should be taken into account. Appropriate PPIs should be selected according to patients' own situation and pharmacochemical characteristics of PPIs, so as to improve the rational use level of PPIs.

R975

国家自然科学基金资助项目（81603361）