目的 探讨参芪降糖颗粒联合米格列醇治疗2型糖尿病的临床疗效。方法 选择2019年9月—2021年9月淮南东方医院集团总医院收治的96例2型糖尿病患者，随机分对照组和治疗组，每组各48例。对照组患者餐前口服米格列醇片，50 mg/次，3次/d。治疗组在对照组基础上口服参芪降糖颗粒，3 g/次，3次/d。两组治疗3个月。观察两组患者临床疗效，比较治疗前后两组患者症状缓解时间，空腹血糖（FPG）、糖化血红蛋白（HbA1c）、餐后2 h血糖（2 h PG）、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、白细胞介素-8（IL-8）水平，及不良反应。结果 治疗后，治疗组临床总有效率明显高于对照组（97.92%vs 81.25%，P<0.05）。治疗后，治疗组多尿、多食、体质量减轻、皮肤瘙痒等症状缓解时间均明显早于对照组（P<0.05）。治疗后，两组患者FPG、HbA1c、P2hPG、IL-6、TNF-α、IL-1β和IL-8水平均明显低于治疗前（P<0.05），且治疗组明显低于对照组（P<0.05）。治疗组不良反应发生率为8.33%，明显低于对照组的16.67%（P<0.05）。结论 参芪降糖颗粒联合米格列醇治疗2型糖尿病，在降低血糖同时，还能降低炎性因子水平，且药物安全有效。

Objective To explore the clinical effect of Shenqi Jiangtang Granules combined with miglitol in treatment of type 2 diabetes. Methods Patients (96 cases) with type 2 diabetes in Huainan Oriental Hospital Group from September 2019 to September 2021 were randomly divided into control and treatment group, and each group had 48 cases. Patients in the control group were po administered with Miglitol Tablets before meals, 50 mg/time, three times daily. Patients in the treatment group were po administered with Shenqi Jiangtang Granules on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical evaluation was evaluated, the relief time symptom, the levels of FPG, HbA1c, 2 h PG, IL-6, TNF-α, IL-1β and IL-8, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (97.92% vs 81.25%, P < 0.05). After treatment, the relief time of polyuria, polyphagia, weight loss and skin pruritus in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the levels of FPG, HbA1c, 2 h PG, IL-6, TNF-α, IL-1β and IL-8 in two groups were significantly lower than those before treatment (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). The incidence of adverse reactions in the treatment group was 8.33%, which was significantly lower than 16.67% in the control group (P < 0.05). Conclusion Shenqi Jiangtang Granules combined with miglitol in treatment of type 2 diabetes can not only reduce the blood sugar of patients, but also reduce the level of inflammatory factors, and the combination is safe and effective.

R977

安徽省卫生和计划生育委员会项目（16-028-02）