目的 建立和胃降逆胶囊的质量标准，为全面提升和胃降逆胶囊的质量控制提供参考。方法 采用薄层色谱（TLC）法定性鉴别和胃降逆胶囊中朱砂七、楤木和蒲公英，采用滴定法测定煅赭石中铁（Fe），采用高效液相色谱法（HPLC）测定虎杖苷、大黄素、白藜芦醇、大黄素-8-O-β-D-葡萄糖苷和大黄素甲醚。结果 朱砂七、楤木和蒲公英的TLC特征斑点清晰，专属性强，分离度好，阴性对照无干扰；样品中Fe的范围为130.665～140.823 mg/g；虎杖苷、大黄素、白藜芦醇、大黄素-8-O-β-D-葡萄糖苷和大黄素甲醚在0.071 4～1.714 3、0.035 7～0.857 2、0.071 4～1.714 3、0.035 7～0.857 2、0.014 3～0.342 8 μg与峰面积呈良好的线性关系，平均加样回收率分别为97.26%、96.28%、100.36%、102.71%、101.36%，RSD值分别为0.81%、2.25%、1.71%、2.85%、2.38%。结论 建立的方法可作为和胃降逆胶囊的质量标准。

Objective To establish the quality standard of Heweijiangni Capsules, to provide reference for the overall improvement of the quality control of Heweijiangni Capsules. Methods TLC method was used to qualitatively identify the Polygoni Ciliinerve Radix, Aralae Cortex, and Taraxaci Herba in Hewei Jiangni Capsules. The content of iron (Fe) in was determined by titration. HPLC method was used to determine polydatin, emodin, resveratrol, emodin-8-O-β-D-pyranoside, and physcion. Results TLC spots of Polygoni Ciliinerve Radix, Aralae Cortex, and Taraxaci Herba were clear, the separation was good, the specificity was strong, and the negative sample had no interference. The content of Fe in the sample was 130.665-140.823 mg/g. The linear ranges of polydatin, emodin, resveratrol, emodin-8-O-β-D-pyranoside, and physcion in Hewei Jiangni Capsules were 0.071 4-1.714 3 μg, 0.035 7-0.857 2 μg, 0.071 4-1.714 3 μg, 0.035 7-0.857 2 μg, and 0.014 3-0.342 8 μg, respectively. The average recoveries were 97.26%, 96.28%, 100.36%, 102.71%, and 101.36%, with RSD values 0.81%, 2.25%, 1.71%, 2.85%, and 2.38%, respectively. Conclusion The established method can be used as quality standard of Hewei Jiangni Capsules.

R286.02

陕西省教育厅科研服务地方专项计划项目（15JF015）；陕西中医药大学学科创新团队项目（2019-YL11）