芦荟大黄素为蒽醌类化合物，主要来源于芦荟、大黄、巴天酸模、山扁豆等植物中，具有良好的抗菌、泻下作用。近年来，研究者在对芦荟大黄素药理活性的研究中发现其有巨大的抗肿瘤潜力。从诱导肿瘤细胞凋亡、抑制肿瘤细胞增殖、抑制肿瘤细胞侵袭和转移、诱导肿瘤细胞自噬、抗炎、免疫调节方面对芦荟大黄素的抗肿瘤作用机制进行综述，为其进一步的应用、开发提供参考。

Aloe-emodin is an anthraquinone compound, mainly from Aloe vera (Linn.) N. L. Burman var. chinensis (Haw.) Berg., Rheum officinale Baill., Rumex patientia Linn., Cassia mimosoides L. and other plants, with good antibacterial and laxative effects. In recent years, researchers have found that aloe-emodin has great anti-tumor potential in its study of the pharmacological activity. This article reviews the anti-tumor mechanisms of aloe-emodin, such as inducing tumor cell apoptosis, inhibiting tumor cell proliferation, inhibiting tumor cell invasion and metastasis, inducing tumor cell autophagy, anti-inflammatory, and immune regulation, to provide reference for its further application and development.

R979.1

国家自然科学基金资助项目(81760491);广西科学技术厅科技开发项目(桂科攻1355004-8);广西医疗卫生适宜技术开发与推广应用项目(S2020106);2022年度广西高校中青年教师科研基础能力提升项目(2022KY0502);桂林市科学研究与技术开发计划项目(20210227-8-7)