目的 分析抗感染药物不良反应（ADR）发生的特点，为临床安全用药提供依据。方法 对咸阳市中心医院2016年1月—2021年12月上报的317例抗感染药物不良反应进行回顾性分析。结果 老年患者（36.28%）最易发生ADR；静脉滴注（89.27%）ADR发生率最高；ADR主要发生在用药31～60 min；引起ADR最多的药物为头孢类，其次是喹诺酮类；ADR的临床表现以皮肤及附件系统损害最多见。结论 医院重视抗感染药物的管理，提高用药合理性，加强用药监测，有效降低不良反应的发生率。

Objective The characteristics of anti-infective adverse drug reactions (ADR) were analyzed to provide evidence for clinical safty drug use. Methods A retrospective research method was conducted to analyze 317 ADR reports in Xianyang Central Hospital from January 2016 to December 2021. Results The elderly patients (36.28%) had the highest incidence of ADR. The incidence of ADR was highset in intravenous drip (89.27%). The most ADR occurred between 31 — 60 min. Cephalosporins caused most ADR, followed by quinolones. The most common clinical manifestations of ADR were skin and accessory lesions. Conclusion In clinical work, medical workers should pay attention to the management of anti-infective drugs, improve the rationality of drug use, strengthen the drug use monitoring, and effectively reduce the probability of adverse reactions.

R978.1