目的 探讨疗癣卡西甫丸联合卡泊三醇乳膏治疗寻常型银屑病的临床疗效。方法 选择2019年6月—2021年6月南阳市中心医院收治的106例寻常型银屑病患者，随机分为对照组和治疗组，每组各53例。对照组外涂卡泊三醇乳膏，取适量均匀涂在患处，2次/d。在对照组基础上，治疗组口服疗癣卡西甫丸，10 g/次，2次/d。所有连续治疗7 d。观察两组患者临床疗效，比较治疗前后两组症状缓解时间，血清因子白细胞介素-2（IL-2）、干扰素-γ（INF-γ）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平及不良反应情况。结果 治疗后，治疗组临床有效率明显高于对照组（98.11%vs 84.91%，P＜0.05）。治疗后，治疗组中瘙痒、红斑丘疹、鳞屑、皮损缓解时间均明显短于对照组（P＜0.05）。治疗后，两组患者血清因子IL-2、INF-γ、TNF-α、IL-6水平明显降低（P＜0.05），且治疗组明显低于对照组（P＜0.05）。治疗期间，治疗组不良反应发生率为7.54%，明显低于对照组的16.98%（P＜0.05）。结论 疗癣卡西甫丸联合卡泊三醇乳膏治疗寻常型银屑病效果明显，可改善机体免疫系统，降低炎症反应。

Objective To explore the curative effect of Liaoxuan Kaxifu Pills combined with Calcipotriol Ointment in treatment of psoriasis vulgaris. Methods Patients (106 cases) with psoriasis vulgaris in Nanyang Central Hospital from June 2019 to June 2021 were randomly divided into control and treatment group, and each group had 53 cases. Patients in the control group were administered with Calcipotriol Ointment, evenly applied proper amount to the affected area, twice daily. Patients in the treatment group were po administered with Liaoxuan Kaxifu Pills on the basis of the control group, 10 g/time, twice daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, the relief time of symptom, levels of serum factor IL-2, INF-γ, TNF-α and IL-6, adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (98.11% vs 84.91%, P < 0.05). After treatment, the relief time of pruritus, erythema papules, scales and skin lesions in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the levels of serum factors IL-6, IL-2, INF-γ and TNF-α were significantly decreased (P < 0.05), and the serum factors levels in the treatment group were significantly lower than those in the control group (P < 0.05). During the treatment period, the incidence of adverse reactions in the treatment group was 7.54%, which was significantly lower than 16.98% in the control group (P < 0.05). Conclusion Liaoxuan Kaxifu Pills combined with Calcipotriol Ointment in treatment of psoriasis vulgaris has obvious curative effect, which can improve the immune system, reduce inflammatory reaction.

R986

河南省中医药科学研究专项课题(2019ZY3036)