目的 探讨复明片联合曲伏前列素滴眼液治疗开角型青光眼的临床疗效。方法 选取2017年10月—2021年1月在洛阳市第三人民医院眼科治疗的142例开角型青光眼患者，根据随机数字法将所有患者分为对照组和治疗组，每组各组71例。对照组外用曲伏前列素滴眼液，睡前1滴/次，1次/d。治疗组在对照组治疗基础上口服复明片，5片/次，3次/d。两组连续用药30 d。观察两组的临床疗效，比较两组临床症状缓解情况，眼动脉血流指标和血清学因子水平。结果 治疗后，治疗组总有效率是98.59%，显著高于对照组的84.51%（P＜0.05）。治疗后，治疗组视力模糊、眼胀、视力下降、头痛缓解时间均显著短于对照组（P＜0.05）。治疗后，两组眼动脉血流阻力指数（RI）、动脉收缩期最大流速（PSV）均较治疗前显著降低，但舒张末期血流速度（EDV）显著升高（P＜0.05）；治疗后，治疗组眼动脉血流指标改善优于对照组（P＜0.05）。治疗后，两组患者血清白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）、干扰素-γ（IFN-γ）、内皮素-1（ET-1）水平均较治疗前显著降低（P＜0.05）；治疗后，治疗组血清因子水平低于对照组（P＜0.05）。结论 复明片联合曲伏前列素滴眼液治疗开角型青光眼具有较好的临床疗效，可明显改善眼部血流指标，能有效降低眼部炎症状态，值得临床推广使用。

Objective To investigate the therapeutic effect of Fuming Tablets combined with Travoprost Eye Drops in treatment of open-angle glaucoma. Methods A total of 142 cases of open-angle glaucoma treated in Luoyang Third People’s Hospital from October 2017 to January 2021 were selected. All patients were divided into control group and treatment group according to random number method, with 71 cases in each group. Patients in the control group were given Travoprost Eye Drops, 1 drop/time before bedtime, once daily. Patients in the control group were po administered with Fuming Tablets on the basis of the control group, 5 tablets/time, 3 times daily. Both groups were treated for 30 d. The clinical efficacy of the two groups was observed, and the clinical symptom relief, ocular artery blood flow index and serological factor levels were compared between the two groups. Results After treatment, the total effective rate in the treatment group was 98.59%, significantly higher than that in the control group (84.51%, P < 0.05). After treatment, the relief time of blurred vision, eye distension, decreased vision, and headache in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the blood flow resistance index (RI) and the maximum systolic flow rate (PSV) were significantly decreased, but the end diastolic flow velocity (EDV) was significantly increased in two groups (P < 0.05). After treatment, the improvement of blood flow index of ocular artery in treatment group was better than that in control group (P < 0.05). After treatment, the levels of serum interleukin-6 (IL-6), interleukin-1 β (IL-1β), interferon-γ(IFN-γ), and endothelin-1 (ET-1) in two groups were significantly decreased compared with before treatment (P < 0.05). After treatment, the level of serum factors in the treatment group was better than that in the control group (P < 0.05). Conclusion Fuming Tablets combined with Travoprost Eye Drops has good clinical effect in treatment of open-angle glaucoma, and can obviously improve the blood flow index of the eye and effectively reduce the inflammatory state of the eye, which is worthy of clinical application.

R988.1

河南省卫建委课题(WjLx2020539)