目的 探究消炎利胆片联合左氧氟沙星片治疗急性胆囊炎的临床疗效。方法 选择2020年1月—2021年1月在安阳市第二人民医院就诊治疗的90例急性胆囊炎患者，按照随机数字表法将所有患者分为对照组和治疗组，每组各45例。对照组口服左氧氟沙星片，0.5 g/次，3次/d；治疗组在对照组的基础上口服消炎利胆片，6片/次，3次/d。两组患者均连续治疗14 d。观察两组的临床疗效，比较两组患者治疗后的临床症状、胆囊壁厚度、胆囊排空率和血清炎性因子。结果 治疗后，治疗组患者的总有效率为95.55%，高于对照组总有效率84.44%，组间比较差异有显著意义（P＜0.05）。治疗后，治疗组患者腹痛消失时间、体温恢复时间、恶心呕吐消失时间明显短于对照组，组间比较有显著差异（P＜0.05）。治疗后，两组患者的胆囊壁厚度较治疗前降低，胆囊排空率较治疗前升高，同组治疗前后比较有显著差异（P＜0.05）；且治疗组患者胆囊壁厚度较对照组降低，胆囊排空率较对照组升高，组间比较有显著差异（P＜0.05）。治疗后，两组患者的血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）水平显著降低，同组治疗前后比较有显著差异（P＜0.05）；且治疗组患者的血清IL-6、TNF-α、CRP水平较对照组降低明显，组间比较有显著差异（P＜0.05）。结论 消炎利胆片联合左氧氟沙星片治疗急性胆囊炎具有较好的临床疗效，改善了患者临床症状，降低了炎性反应，值得临床上借鉴。

Objective To explore the clinical study of Xiaoyan Lidan Tablets combined with Levofloxacin Tablets in treatment of acute cholecystitis. Methods Patients (90 cases) with acute cholecystitis in The Second People’s Hospital of Anyang from January 2020 to January 2021 were divided into control and treatment groups according to random number table method, and each group had 45 cases. Patients in the control group were po administered with Levofloxacin Tablets, 0.5 g/time, three times daily. Patients in the treatment group were po administered with Xiaoyan Lidan Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the clinical symptoms, gallbladder wall thickness, gallbladder emptying rate, and serum inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.55%, which was higher than 84.44% of the control group, and there was significant difference between two groups (P < 0.05). After treatment, the disappearance time of abdominal pain, the recovery time of body temperature, and the disappearance time of nausea and vomiting in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the gallbladder wall thickness of two groups was lower than that before treatment, and the gallbladder emptying rate of two groups was higher than that before treatment, and there was significant difference between two groups (P < 0.05). The thickness of gallbladder wall in the treatment group was lower than that in the control group, and the gallbladder emptying rate in the treatment group was higher than that in the control group, and there was significant difference between two groups (P < 0.05). After treatment, the serum levels of IL-6, TNF-α, and CRP in two groups were significantly lower than those in the same group (P < 0.05), and the serum levels of IL-6, TNF-α, and CRP in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Xiaoyan Lidan Tablets combined with Levofloxacin Tablets has clinical curative effect in treatment of acute cholecystitis, can improve the clinical symptoms, and reduce the inflammatory reaction, which is worthy of clinical reference.

R975

国家自然科学基金资助项目(81804057)