[关键词]
[摘要]
目的 探讨脑脉利颗粒联合曲克芦丁治疗急性脑梗死临床疗效。方法 选取2019年7月-2021年7月在濮阳市油田总医院脑治疗的134例急性脑梗死患者,按照随机数字表法分为对照组和治疗组,每组各67例。对照组静脉滴注曲克芦丁注射液, 240 mg溶于5%葡萄糖注射液250 mL中, 1次/d。治疗组在对照组基础上口服脑脉利颗粒, 1袋/次, 3次/d。两组患者连续治疗7 d。观察两组患者临床疗效,比较治疗前后两组患者症状好转时间,美国国立卫生研究院卒中量表(NIHSS)评分和生活自理能力(BI)评分,血清炎性因子白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)和超敏C反应蛋白(hs-CRP)水平及不良反应情况。结果 治疗后,治疗组患者总有效率明显高于对照组(98.51% vs 85.07%,P<0.05)。治疗后,治疗组临床症状好转时间明显早于对照组(P<0.05)。治疗后,两组NIHSS评分明显下降,而BI评分明显升高(P<0.05),且治疗组NIHSS和BI评分明显好于对照组(P<0.05)。治疗后,两组患者血清炎性因子IL-6、IL-8、TNF-α、CRP水平明显下降(P<0.05),且治疗组血清炎性因子水平明显低于对照组(P<0.05)。治疗组不良反应发生率明显低于对照组(7.46% vs 14.93%, P<0.05)。结论 脑脉利颗粒联合曲克芦丁治疗可发挥协同作用,有助于患者脑神经功能的改善,并能降低局部炎症反应。
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[Abstract]
Objective To explore the clinical effect of Naomaili Granules combined with troxerutin in treatment of acute cerebral infarction.Methods Patients (134 cases) with acute cerebral infarction in Puyang Oilfield General Hospital from July 2019 to July 2021 were randomly divided into control and treatment group, and each group had 67 cases. Patients in the control group were iv administered with Troxerutin Injection, 200 mg added into 5% glucose injection 250 mL, once daily. Patients in the treatment group were po administered with Naomaili Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, the improvement time to clinical symptom, the scores of BI and NIHSS, the levels of inflammatory factors IL-6, IL-8, TNF-α, and CRP, and adverse reactions in two groups before and after treatment were compared.Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (98.51% vs 85.07%, P < 0.05). The improvement time of symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the NIHSS score in two groups were significantly decreased, while the Bi score were significantly increased (P < 0.05), and the scores of the treatment group were significantly better than those of the control group (P < 0.05). After treatment, the levels of serum inflammatory factors IL-6, IL-8, TNF-α, and CRP in two groups were significantly decreased (P < 0.05), and the levels of serum inflammatory factors in the treatment group were significantly lower than those in the control group (P < 0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (7.46% vs 14.93%, P < 0.05).Conclusion The combination of Naomaili Granules and troxerutin can improve the function of brain inflammation and reduce the local inflammation of patients.
[中图分类号]
R971
[基金项目]
河南省医学科技攻关计划项目(163509110089)