目的 探讨小儿柴桂退热颗粒联合头孢呋辛酯治疗小儿急性上呼吸道感染的临床效果。方法 选取2020年5月-2021年4月驻马店市中心医院妇女儿童医院收治的207例急性上呼吸道感染患儿,使用随机数字表法分成对照组(103例)和治疗组(104例)。对照组口服头孢呋辛酯胶囊,0.125 g/次,2次/d。在对照组基础上,治疗组口服小儿柴桂退热颗粒,1~3岁患儿5 g/次、4~6岁7.5 g/次、7~12岁10 g/次,4次/d。两组患儿均连续治疗5 d。观察两组患者临床疗效,比较治疗前后两组患者退热效果,主要症状消失时间,外周血白细胞计数(WBC),及血清降钙素原(PCT)、淀粉样蛋白A(SAA)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)水平。结果 治疗后,治疗组总有效率为94.2%,较对照组的81.6%显著升高(P<0.05)。治疗后,治疗组即刻退热率为49.0%,显著高于对照组的32.0%(P<0.05),治疗组退热起效时间和体温复常时间均显著短于对照组(P<0.05)。治疗后,治疗组鼻塞、流涕和咽部红肿消失时间较对照组均显著缩短(P<0.05)。治疗后,两组外周血WBC及血清PCT、SAA、IL-8和TNF-α水平均显著下降(P<0.05),且治疗组降低作用较对照组更显著(P<0.05)。结论 小儿柴桂退热颗粒联合头孢呋辛酯对急性上呼吸道感染患儿具有确切的临床疗效,可安全有效且迅速地缓解患儿症状,退热效果显著,并能抑制炎症反应。

Objective To investigate the clinical effect of Xiaoer Chaigui Tuire Granules combined with cefuroxime axetil in treatment of children with acute upper respiratory tract infection. Methods Children (207 cases) with acute upper respiratory tract infection in Women and Children Hospital, Zhumadian Central Hospital from May 2020 to April 2021 were divided into control (103 cases) and treatment (104 cases) group by the random number table method. Children in the control group were po administered with Cefuroxime Axetil Capsules, 0.125 g/time, twice daily. Children in the treatment group were po administered with Xiaoer Chaigui Antipyretic Granules on the basis of the control group, 5 g/time for 1 — 3 years old, 7.5 g/time for 4 — 6 years old, 10 g/time for 7 — 12 years old, four times daily. Children in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, the effect of antipyretic, the disappearance time of main symptoms, the levels of WBC and serum PCT, SAA, IL-8, and TNF-α in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the treatment group was 94.2%, which was significantly higher than 81.6% in the control group (P < 0.05). After treatment, the immediate antipyretic rate in the treatment group was 49.0%, which was significantly higher than 32.0% in the control group (P < 0.05), and the onset time of antipyretic and the recovery time of body temperature in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, time for nasal congestion, runny nose and pharyngeal redness to disappear in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the concentration of the peripheral blood WBC and serum PCT, SAA, IL-8, and TNF-α in two groups were significantly decreased (P < 0.05), and the decreasing effect of the treatment more significant than that of the control group (P < 0.05). Conclusion Xiaoer Chaigui Tuire Granules combined with cefuroxime axetil in treatment of children with acute upper respiratory tract infection has definite clinical effect, can safely, effectively and quickly alleviate the symptoms, has significant antipyretic effect, and can inhibit inflammatory reaction.

R974