目的 了解海南省人民医院2012—2019年重点监控药物的临床使用情况，为安全、有效、经济的药品使用提供参考。方法 采用回顾性分析方法收集海南省人民医院2012年1月—2019年12月重点监控药物处方，分析重点监控药物的处方占比、使用人次占比、种类、使用金额和科室占比。结果 海南省人民医院2012—2019年重点监控药物的处方占比和使用人次占比逐年下降；在26种重点监控药物中，以复合辅酶、二丁酰环磷腺苷钙、马来酸桂哌齐特、前列地尔和丹参川芎嗪处方数较多；而单唾液酸四己糖神经节苷脂钠、二丁酰环磷腺苷钙、马来酸桂哌齐特、前列地尔和依达拉奉的使用金额较多；重点监控药物的使用多集中于医疗保健、心血管内科、神经内科、神经外科、胃肠外科、脊柱外科、儿科和老年病科等。结论 海南省人民医院2012—2019年的重点监控药物使用有所控制，然而部分药物如复合辅酶和部分科室如儿科对重点监控药物的应用仍需密切关注。

Objective To investigate the prevalence of key monitoring drugs in Hainan General Hospital from 2012 to 2019 to improve the rational use of key monitoring drug. Methods The prescriptions of key monitored drugs in Hainan Provincial People's Hospital from January 2012 to December 2019 were collected by retrospective analysis, and the proportion of prescriptions, the proportion of patients, types, consumption sum and department proportion of key monitored drugs were analyzed. Results From 2012 to 2019, the proportion of prescriptions and times of key monitored drugs in Hainan Provincial People's Hospital decreased year by year. Among 26 key monitoring drugs, compound coenzyme, dibutyryl cyclic adenosine calcium, cinnampiazide maleate, alpropil and salvia miltiorrhiza ligustrazine were the most frequently prescribed drugs. The amount of sodium monosialate tetrohexose ganglioside, calcium dibutyl cyclic adenosine phosphate, cinnampiazide maleate, alprostadil and edaravone were higher. The use of key monitoring drugs is mainly concentrated in medical care, cardiovascular medicine, neurology, neurosurgery, gastrointestinal surgery, spine surgery, pediatrics and geriatrics. Conclusion The utilization of key monitoring drugs in Hainan General Hospital was controlled from 2012 to 2019. However, some drugs such as compound coenzyme and some departments such as pediatrics still need to pay close attention to the application of key monitored drugs.

R95

海南省自然科学基金资助项目（819QN224）