目的 观察小儿肺热咳喘颗粒治疗小儿支气管哮喘的临床疗效和安全性。方法 选择2016年7月—2018年4月在丹东市中医院110例小儿支气管哮喘患儿为研究对象，随机分成对照组和治疗组，每组各55例。两组均给予基础治疗。对照组口服小儿肺热咳喘颗粒模拟剂，1～2岁1袋/次，3次/d；3～5岁1袋/次，4次/d。治疗组口服小儿肺热咳喘颗粒，1～2岁1袋/次，3次/d；3～5岁1袋/次，4次/d。两组患儿连续服药28 d。观察两组患儿临床疗效，比较治疗前后两组患儿肺功能指标用力肺活量（FVC）、第1秒用力呼气量（FEV1）、FEV1占FVC比值（FEV1/FVC）、最大呼气流速（PEF）、肺活量（VC）及中医证候疗效。结果 治疗后，治疗组患儿总有效率为89.09%，明显高于对照组的72.73%（P<0.05）。治疗后，治疗组患儿FEV1、FEV1/FVC、PEF、VC均明显高于对照组（P<0.05）。治疗后，治疗组患儿中医证候有效率在14、28 d分别为70.91%、92.72%；对照组患儿分别为50.91%和78.18%，两组比较差异具有统计学意义（P<0.05）。结论 小儿肺热咳喘颗粒治疗小儿支气管哮喘患儿临床效果好且未观察到不良反应，具有一定的临床推广应用价值。

Objective To observe the efficacy and safety of Xiaoer Feire Kechuan Granules in treatment of children with bronchial asthma. Methods Children (110 cases) with bronchial asthma in Dandong Hospital of Traditional Chinese Medicine from July 2016 to April 2018 were randomly divided into control and treatment groups, and each group had 55 cases. Children in two groups were administered with basic treatment. Children in the control group were po administered with Xiaoer Feire Kechuan Granules simulator, 1 bag/time for 1-2 years old children, three times daily, 1 bag/time for 3-5 years old children, four times daily. Children in the treatment group were po administered with Xiaoer Feire Kechuan Granules, 1 bag/time for 1-2 years old children, three times daily, 1 bag/time for 3-5 years old children, four times daily. Children in two groups were treated for 28 d. After treatment, the clinical efficacy was evaluated, the pulmonary function indexes of FEV1, FEV1/FVC, PEF and VC, and the curative effect of TCM syndromes in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the treatment group was 89.09%, which was significantly higher than 72.73% in the control group (P < 0.05). After treatment, the levels of FEV1, FEV1/FVC, PEF and VC in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, the effective rate of TCM syndrome in the treatment group was 70.91% and 92.72% on 14 d and 28 d, while those in the control group was 50.91% and 78.18%, respectively, and the difference between the two groups was statistically significant (P < 0.05). Conclusion Xiaoer Feirre Kechuan Granules has a good clinical effect in the treatment of children with bronchial asthma and no adverse reactions were observed, which has a certain clinical application value.

R974;R985