目的 探讨金蚧片联合伐地那非治疗勃起功能障碍的临床疗效。方法 选取2018年11月—2020年11月在天津市泰达医院泌尿外科门诊治疗的96例勃起功能障碍患者，根据随机数字表法分为对照组和治疗组，每组各48例。对照组口服盐酸伐地那非片，10 mg/次，在性交前25～60 min服用。治疗组在对照组的基础上口服金蚧片，4片/次，3次/d。两组连续服用药物8周。观察两组的临床疗效，比较两组治疗前后阴茎血流动力学指标、国际勃起功能评分-5（IIEF-5）、勃起硬度评分（EHS）、睾酮水平变化情况。结果 治疗后，治疗组总有效率是97.92%，显著高于对照组的81.25%（P<0.05）。治疗后，治疗组患者阴茎血流动力学中舒张末期峰值流速（EDV）、血流阻力指数（RI）均高于对照组，但收缩期峰值流速（PSV）低于对照组（P<0.05）；且治疗后，治疗组患者阴茎血流动力学中各指标改善优于对照组（P<0.05）。治疗后，两组患者IIEF-5、EHS评分均显著升高；治疗后，治疗组IIEF-5、EHS评分均显著高于对照组（P<0.05）。治疗后，两组患者睾酮水平显著升高（P<0.05），且治疗后治疗组睾酮水平高于对照组（P<0.05）。结论 金蚧片联合伐地那非治疗勃起功能障碍疗效显著，可有效改善阴茎勃起功能，且具有较高的治疗安全性，值得临床借鉴与推广。

Objective To investigate the therapeutic effect of Jinjie Tablet combined with vardenafil in treatment of erectile dysfunction. Methods A total of 96 patients with erectile dysfunction treated in the Urology Department of TEDA Hospital from November 2018 to November 2020 were selected and divided into control group and treatment group according to random number table method, with 48 patients in each group. Patients in the control group were po administered with Vardenafil Hydrochloride Tablets, 10 mg/time, 25 to 60 minutes before intercourse. Patients in the treatment group were po administered with Jinjie Tablet on the basis of the control group, 4 tablets/time, three times daily. Both groups took the drug for eight weeks. The clinical efficacy of the two groups were observed, and the changes of penile hemodynamic indexes, international erectile function score -5 (IIEF-5), erectile hardness score (EHS) and testosterone levels were compared between the two groups before and after treatment. Results After treatment, the total effective rate in the treatment group was 97.92%, significantly higher than that in the control group (81.25%, P < 0.05). After treatment, EDV and RI indexes of penile hemodynamics in treatment group were higher than control group, but PSV was lower than control group (P < 0.05). Moreover, after treatment, all indexes of penile hemodynamics in the treatment group were improved better than those in the control group (P < 0.05). After treatment, IIEF-5 and EHS scores were significantly increased in two groups. After treatment, IIEF-5 and EHS scores in treatment group were significantly higher than those in control group (P < 0.05). After treatment, the level of testosterone in two groups was significantly increased (P < 0.05), and the level of testosterone in treatment group was higher than that in control group (P < 0.05). Conclusion Jinjie Tablet combined with vardenafil has good clinical effect in treatment of erectile dysfunction, and can effectively improve penile erection function, and has a high therapeutic safety, which is worthy of clinical reference and promotion.

R983

天津市卫生计划委员会科技项目（ZC20208）