目的 探究满金止咳片联合吸入用异丙托溴铵溶液治疗慢性支气管炎的疗效及其对白细胞介素2受体（IL-2R）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）水平的影响。方法 选取2018年12月—2020年12月在郑州大学附属洛阳中心医院治疗的102例慢性支气管炎患者。按照随机数字表法将患者分为对照组和治疗组，每组各51例。对照组患者雾化吸入吸入用异丙托溴铵溶液，2 mL/次，2次/d。治疗组在对照组的基础上口服满金止咳片，5片/次，3次/d。两组患者均治疗3个月。观察两组患者的临床疗效，比较两组患者症状缓解时间、肺功能指标[达峰时间比（tPTEF/tE）、达峰容积比（VPEF/VE）、潮气量（VT）、呼吸频率（RR）]、血气指标[二氧化碳分压（pCO₂）、动脉血氧分压（pO₂）、血清酸碱度（pH值）]和血清炎性因子（IL-2R、IL-6、IL-8、IL-10）水平。结果 治疗后，治疗组总有效率为88.24%，对照组总有效率为64.71%，对照组总有效率明显降低于治疗组（P<0.05）。治疗后，治疗组咳嗽、气喘、肺部湿啰音消失时间与对照组比较均明显缩短（P<0.05）。治疗后，两组tPTEF/tE、VPEF/VE、VT水平均明显升高，RR水平明显降低（P<0.05），且与对照组比较，治疗组tPTEF/tE、VPEF/VE、VT水平明显高于对照组，RR水平明显低于对照组（P<0.05）。治疗后，两组pO₂、pH值均明显升高，pCO₂水平明显降低（P<0.05），且治疗后，治疗组pO₂、pH值明显高于对照组，pCO₂水平明显低于对照组（P<0.05）。治疗后，两组血清IL-2R、IL-6、IL-8水平均明显降低，血清IL-10水平明显升高（P<0.05），且治疗后，治疗组血清IL-2R、IL-6、IL-8水平低于对照组，血清IL-10水平高于对照组（P<0.05）。结论 满金止咳片联合吸入用异丙托溴铵溶液治疗慢性支气管炎可有效改善患者临床症状，提高肺功能，调节血气指标，减轻炎症反应，安全性较好。

Objective To explore the clinical study of Manjin Zhike Tablets combined with Ipratropium Bromide Solution for inhalation in treatment of chronic bronchitis and its influences on the levels of IL-2R, IL-6, IL-8, and IL-10. Methods Patients (102 cases) with chronic bronchitis in Luoyang Central Hospital Affiliated to Zhengzhou University from December 2018 to December 2020 were randomly divided into control and treatment groups, and each group had 51 cases. Patients in the control group were atomization inhalation administered with Ipratropium Bromide Solution for inhalation, 2 mL/time, twice daily. Patients in the treatment group were po administered with Manjin Zhike Tablets on the basis of the control group, 5 tablets/time, three times daily. Patients in two groups were treated for 3 weeks. After treatment, the clinical efficacies were evaluated, and the symptom relief time, pulmonary function indexes (tPTEF/tE, VPEF/VE, VT, and RR), blood gas indexes (pCO₂,pO₂, and pH value), and serum inflammatory factor in two groups were compared. Results After treatment, the total effective rate in the control group (64.71%) was significantly lower than 88.24% in the treatment group (P < 0.05). After treatment, the disappearance time of cough, asthma, and lung wet rales in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the levels of tPTEF/tE, VPEF/VE, and VT in two groups were significantly increased, but the levels of RR were significantly decreased (P < 0.05). Compared with the control group, the levels of tPTEF/tE, VPEF/VE, and VT in the treatment group were significantly higher than those in the control group, but the level of RR was significantly lower than that in the control group (P < 0.05). After treatment, the pO₂ and pH value in two groups were significantly increased, but the level of pCO₂ in two groups were significantly decreased (P < 0.05). After treatment, the pO₂ and pH value in the treatment group were significantly higher than those in the control group, but the level of pO₂ in the treatment group was significantly lower than that in the control group (P < 0.05). After treatment, the serum levels of IL-2R, IL-6, and IL-8 in two groups were significantly decreased, but the serum level of IL-10 were significantly increased (P < 0.05). After treatment, the serum levels of IL-2R, IL-6, and IL-8 in the treatment group were lower than those in the control group, but the serum level of IL-10 in the treatment group was higher than those in the control group (P < 0.05). Conclusion Manjin Zhike Tablets combined with Ipratropium Bromide Solution for inhalation in treatment of chronic bronchitis can effectively improve the clinical symptoms of patients, improve lung function, regulate blood gas indexes, reduce inflammatory reaction, with good safety.

R974

河南省医学科技攻关计划省部共建项目（SB201902028）