[关键词]
[摘要]
目的 探讨安坤颗粒联合卡前列甲酯栓治疗产后出血的临床疗效。方法 选择2017年2月—2019年10月在天津市第一中心医院进行治疗的106例产后出血患者,根据用药差别分为对照组和治疗组,每组各53例。对照组给予卡前列甲酯栓,戴无菌手套后将卡前列甲酯栓1 mg放入阴道,贴附于阴道前壁下1/3处,约2 min,1次/d;治疗组在对照组基础上口服安坤颗粒,10 g/次,2次/d。两组均经7 d治疗。观察两组的临床疗效,比较两组治疗2 h、24 h出血量及止血时间,凝血指标和子宫血流动力学指标。结果 治疗后,治疗组总有效率98.11%,显著高于对照组的84.91%(P<0.05)。经治疗,治疗组治疗2 h、24 h出血量均显著少于对照组,且止血时间明显短于对照组(P<0.05)。经治疗,两组血清凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血酶原时间(APTT)均较治疗前降低,而纤维蛋白原(FIB)增高(P<0.05);治疗后,治疗组凝血指标改善优于对照组(P<0.05)。经治疗,两组子宫动脉收缩期血流速度(PSV)显著升高,但阻力指数(RI)、搏动指数(PI)均明显降低(P<0.05);治疗后,治疗组子宫血流动力学指标改善优于对照组(P<0.05)。结论 安坤颗粒联合卡前列甲酯栓治疗产后出血的效果良好,有利于促进子宫收缩,改善机体凝血功能,具有很好的临床应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Ankun Granules combined with Carboprost Methylate Suppositories in treatment of postpartum hemorrhage. Methods A total of 106 cases of postpartum hemorrhage patients treated in Tianjin First Central Hospital from February 2017 to October 2019 were selected and divided into control group and treatment group according to the difference of medication, with 53 cases in each group. Patients in the control group were administered with Carboprost Methylate Suppositories, after wearing sterile gloves, put 1 mg Carboprost Methylate Suppositories into the vagina and attach it to the lower 1/3 of the anterior vaginal wall for about 2 min, once daily. Patients in the treatment group were po administered with Ankun Granules on the basis of the control group, 10 g/time, twice daily. Both groups were treated for 7 d. The clinical efficacy of the two groups was observed, and the blood loss after 2 h and 24 h treatment, hemostatic time, coagulation indexes and uterine hemodynamics indexes were compared between the two groups. Results After treatment, the total effective rate of treatment group was 98.11%, which was significantly higher than that of control group (84.91%) (P < 0.05). After treatment, the blood loss of 2 h and 24 h after treatment in the treatment group was significantly less than that in the control group, and the hemostatic time was significantly shorter than that in the control group (P < 0.05). After treatment, the serum prothrombin time (PT), thrombin time (TT) and activated partial prothrombin time (APTT) in two groups were decreased compared with those before treatment, while the serum fibrinogen (FIB) was increased (P < 0.05). After treatment, the improvement of coagulation index in treatment group was better than that in control group (P < 0.05). After treatment, uterine artery systolic blood flow velocity (PSV) was significantly increased, but resistance index (RI) and pulse index (PI) were significantly decreased in both groups (P < 0.05). After treatment, the improvement of uterine hemodynamics in the treatment group was better than that in the control group (P < 0.05). Conclusion Ankun Granules combined with Carboprost Methylate Suppositories has good effect in treatment of postpartum hemorrhage, and is beneficial to promote uterine contraction and improve the body's coagulation function, which has a good clinical application value.
[中图分类号]
R984
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