目的 探讨利拉鲁肽联合二甲双胍治疗多囊卵巢综合征对患者卵巢功能障碍的影响。方法 选取2019年3月—2020年3月在上海市金山区亭林医院就诊的112例多囊卵巢综合征患者，随机分为对照组（56例）和治疗组（56例）。对照组口服盐酸二甲双胍片，0.5 g/次，3次/d。治疗组在对照组的基础上皮下注射利拉鲁肽注射液，0.6 mg/次，1次/d，连续用药7 d后，剂量增至1.2 mg/次。两组患者持续治疗16周。观察两组患者临床疗效，比较治疗前后两组患者体质量指数（BMI）、空腹血糖（FBG）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）、月经周期率、抗苗勒氏管激素（AMH）、血清性激素、卵泡数目、卵巢体积、卵巢间质面积（SA）和卵巢总面积（TA）。结果 治疗后，两组患者BMI、FBG、FINS、HOMA-IR、AMH、促黄体生成素（LH）、促卵泡刺激素（FSH）、总睾酮（T）、雌二醇（E2）及卵泡数目、卵巢体积、SA和TA均明显降低（P<0.05），且治疗组上述指标降低更明显（P<0.05）。结论 利拉鲁肽联合二甲双胍治疗多囊卵巢综合征的临床效果更佳，且能改善患者卵巢功能障碍问题。

Objective To investigate the effect of liraglutide combined with metformin on ovarian dysfunction in women with polycystic ovary syndrome. Methods Women (112 cases) with polycystic ovary syndrome in Tinglin Hospital of Shanghai Jinshan District from March 2019 to March 2020 were randomly divided into control (56 cases) and treatment (56 cases) groups. Women in the control group were po administered with Metformin Hydrochloride Tablets, 0.5 g/time, three times daily. Women in the treatment group were sc administered with Liraglutide Injection, 0.6 mg/time, once daily, and the dose increased to 1.2 mg/time after 7 d. Patients in two groups were treated for 16 weeks. After treatment, the clinical efficacy was evaluated, the BMI, FBG, FINS, HOMA-IR, menstruation rate, AMH, serum sex hormone, follicles number, ovarian volume, SA, and TA in two groups before and after treatment were compared. Results After treatment, BMI, FBG, FINS, HOMA-IR, AMH, LH, FSH, T, E₂, number of follicles, ovarian volume, SA and TA were significantly decreased in two groups (P < 0.05), and the above indexes were decreased more significantly in the treatment group (P < 0.05). Conclusion Metformin combined with liralutide is more effective in treatment of polycystic ovary syndrome and can improve the ovarian dysfunction of patients.

R984

第六周期金山区医学重点专科建设项目（JSZK2019B02）