[关键词]
[摘要]
目的 观察香橘丸联合双歧杆菌三联活菌治疗儿童胃肠功能性消化不良的临床疗效。方法 选择2018年1月—2019年12月在鄂东医疗集团黄石市妇幼保健院儿童保健中心就诊的243例儿童胃肠功能性消化不良患儿,根据随机数字表法分为对照组(121例)和治疗组(122例)。对照组饭后温开水口服双歧杆菌三联活菌胶囊,2~5岁1粒/次,5岁以上2粒/次,3次/d。治疗组在对照组治疗基础上口服小儿香橘丸,1丸/次,3次/d嚼服,也可分份吞服。两组均连续治疗40 d。观察两组的临床疗效,比较两组营养及胃肠功能状况指标、血清学指标的变化情况。结果 治疗后,治疗组总有效率92.6%,显著高于对照组的87.6%(P<0.05)。治疗后,两组胃肠反应面积(RA)、餐后功率比均显著降低,但Kaup指数、体质量指数显著升高(P<0.05);治疗后,治疗组营养及胃肠功能状况指标改善优于对照组(P<0.05)。治疗后,两组血清乙酰胆碱酯酶(AchE)、应激蛋白(SP)均较治疗前显著升高,但胆囊收缩素(CCK)均显著降低(P<0.05);治疗后,治疗组AchE、SP均高于对照组,但CCK低于对照组(P<0.05)。结论 香橘丸联合双歧杆菌三联活菌治疗儿童胃肠功能性消化不良具有较好的临床疗效,可以调节胃肠功能状况指标和AchE、CCK、SP水平,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To study the clinical effect of Xiangju Pills combined with bifidobacterium triplet living bacterium in treatment of functional gastrointestinal dyspepsia in children. Methods A total of 243 children with gastrointestinal functional dyspepsis who were admitted to the Child Health Care Center of Huangshi Maternal and Child Health-Care Hospital of Edong Medical Group from January 2018 to December 2019 were selected and divided into the control group (121 cases) and the treatment group (122 cases) according to the random number table method. Patients in the control group were po administered with Bifidobacterium Triplet Living Bacterium Capsules, 2-5 years old, 1 grain/time, over 5 years old, 2 grains/time, 3 times daily. Patients in the treatment group were po administered with Xiangju Pills on the basis of the control group, 1 pill/time, 3 times daily chewing, and they can also be divided into swallow. Both groups were treated for 40 d. The clinical efficacy of the two groups were observed, and the changes of nutrition, gastrointestinal function and serological indexes between the two groups were compare. Results After treatment, the total effective rate of treatment group was 92.6%, which was significantly higher than that of control group (87.6%) (P < 0.05). After treatment, gastrointestinal response area (RA) and postpranpranal power ratio were significantly decreased in two groups, but Kaup index and body mass index were significantly increased (P < 0.05). After treatment, the improvement of nutrition and gastrointestinal function in the treatment group was better than that in the control group (P < 0.05). After treatment, the serum acetylcholinesterase (AchE) and stress protein (SP) in two groups were significantly increased compared with before treatment, but the serum cholecystokinin (CCK) was significantly decreased (P < 0.05). After treatment, AchE and SP in treatment group were higher than those in control group, but CCK was lower than that in control group (P < 0.05). Conclusion Xiangju Pills combined with bifidobacterium triplet living bacterium has good clinical effect in treatment of functional gastrointestinal dyspepsia in children, and can regulate gastrointestinal function and AchE, CCK and SP levels, which has certain clinical application value.
[中图分类号]
R975;R985
[基金项目]
湖北省卫生健康委员会联合基金项目(WJ2019H083)