目的 分析2015—2020年兰州大学第一医院血流感染中鲍曼不动杆菌的临床分布特征、抗菌药物耐药性变迁及感染的危险因素，为医院感染的控制和临床合理治疗提供参考。方法 对2015—2020年兰州大学第一医院住院感染患者血培养阳性标本中分离出的鲍曼不动杆菌菌株的科室分布、抗菌药物耐药性特点及危险因素进行分析。结果 2015—2020年兰州大学第一医院住院感染患者血培养阳性标本中共分离到104株鲍曼不动杆菌，主要来源于重症监护病房（ICU）、老年病科、血液科。鲍曼不动杆菌对多种抗菌药物的耐药率超过90%以上。基础疾病、入住ICU、侵袭性操作及使用抗生素成为影响鲍曼不动杆菌血流感染的危险因素。结论 血流感染中分离的鲍曼不动杆菌对常见抗菌药物普遍耐药，应加强医院感染控制，防止耐药菌播散性。

Objective To analyze the clinical distribution characteristics of Acinetobacter baumannii in bloodstream infection, the changes of antimicrobial resistance and the risk factors of infection, so as to provide reference for the control and clinical rational treatment of nosocomial infection.Methods The department distribution, characteristics of antimicrobial resistance and risk factors of A. baumannii strains isolated from positive blood culture samples in the First Hospital of Lanzhou University from 2015 to 2020 were analyzed.Results 104 A. baumannii strains were mainly from ICU, geriatrics and hematology departments. Resistance rate of A. baumannii to antimicrobial drugs more than 90%. Underlying diseases, ICU admission, invasive procedures, and antibiotic use were risk factors for A. baumannii bloodstream infection.Conclusion A. baumannii isolated from bloodstream infection are generally resistant to common antimicrobial agents, so the control of nosocomial infection should be strengthened to prevent the spread of drug-resistant bacteria.

R969.3

兰州大学第一医院院内基金资助项目（ldyyyn2017-05）