[关键词]
[摘要]
目的 探讨头风痛胶囊联合倍他司汀治疗血管性头痛的疗效及对血清细胞因子的影响。方法 选取2019年5月—2020年5月在天津医科大学宝坻临床学院进行诊断治疗的122例血管性头痛患者,依据药物使用的差别将所有患者分成对照组和治疗组,每组各61例。对照组口服盐酸倍他司汀片,8 mg/次,3次/d;治疗组在对照组治疗基础上口服头风痛胶囊,1.5 g/次,2次/d。两组均治疗8周。观察两组的临床疗效和临床症状缓解情况,比较两组生活质量评分(SF-36)、匹兹堡睡眠质量指数量表(PSQI)、疼痛视觉模拟评分(VAS)、血清β内咖啡肽(β-EP)、同型半胱氨酸(Hcy)、降钙素基因相关肽(CGRP)、P物质(SP)水平。结果 治疗后,治疗组总有效率是96.72%,显著高于对照组的83.61%(P<0.05)。治疗后,两组头痛发作次数显著减少,头痛发作持续时间明显缩短(P<0.05);治疗后,治疗组头痛发作次数少于对照组,头痛发作持续时间短于对照组(P<0.05)。治疗后两组SF-36评分显著升高,但PSQI评分、VAS评分都明显降低(P<0.05);治疗后,治疗组相关量表评分改善情况优于对照组(P<0.05)。治疗后两组血清β-EP显著升高,但Hcy、CGRP、SP水平均显著降低(P<0.05);治疗后,治疗组血清学指标改善优于对照组(P<0.05)。结论 头风痛胶囊联合倍他司汀治疗血管性头痛疗效显著,同时还能改善患者临床体征和生活质量,调节血清学指标水平,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the effect of Toufengtong Capsules combined with betahistine in treatment of vascular headache and its effect on serum cytokines.Methods A total of 122 patients with vascular headache who were diagnosed and treated in Baodi Clinical College of Tianjin Medical University from May 2019 to May 2020 were selected. All the patients were divided into control group and treatment group according to the difference of drug use, with 61 cases in each group. Patients in the control group were po administered with Betahistine Hydrochloride Tablets, 8 mg/time, three times daily. Patients in the treatment group were po administered with Toufengtong Capsules on the basis of the control group, 1.5 g/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy and the remission of clinical symptoms in two groups was evaluated, and the levels of life quality score (SF-36), Pittsburgh Sleep Quality Index (PSQI), visual analog scale of pain (VAS), serum β-caffeinin (β-EP), homocysteine (Hcy), calcitonin gene-related peptide (CGRP), and substance P (SP) levels were compared between the two groups.Results After treatment, the total effective rate of the treatment group was 96.72%, which was significantly higher than that of the control group (83.61%,P<0.05). After treatment, the frequency and duration of headache attacks in both groups were significantly decreased (P<0.05). After treatment, the frequency and duration of headache attacks in the treatment group were less than those in the control group (P<0.05). After treatment, SF-36 scores in both groups were significantly increased, but PSQI scores and VAS scores were significantly decreased (P<0.05). After treatment, the improvement of related scale scores in the treatment group was better than that in the control group (P<0.05). After treatment, serum β-EP in both groups was significantly increased, but the levels of Hcy, CGRP and SP were significantly decreased (P<0.05). After treatment, the improvement of serological indexes in the treatment group was better than that in the control group (P<0.05).Conclusion Toufengtong Capsules combined with betahistine has curative effect in treatment of vascular headache, and can also improve the clinical signs and life quality of patients, and also can regulate the level of serological indicators, which has a certain value of clinical application.
[中图分类号]
R971
[基金项目]