目的 探讨脑得生片联合长春西汀注射液治疗脑出血恢复期的临床疗效。方法 选择2017年7月—2019年8月在河南宏力医院治疗的92例脑出血恢复期患者，采用双色球随机分成对照组和治疗组，每组各46例。对照组静脉滴注长春西汀注射液，每次20 mg加入生理盐水500 mL，必要时可增至30 mg/次，1次/d；治疗组在对照组基础上口服脑得生片，6片/次，3次/d。两组患者均治疗2周。观察两组患者临床疗效，比较治疗前后两组患者NIHSS评分、FMA评分和Barthel指数，及血清神经损伤指标胶质纤维酸性蛋白（GFAP）、星形胶质原性蛋白（S100β）、髓鞘碱性蛋白（MBP）、神经元特异性烯醇化酶（NSE）和脑源性神经营养因子（BDNF）水平。结果 治疗后，对照组总有效率为80.43%，显著低于治疗组的97.83%（P<0.05）。治疗后，两组NIHSS评分显著降低，FMA评分和Barthel指数显著升高（P<0.05），且治疗组改善最明显（P<0.05）。治疗后，两组血清GFAP、S100β和MBP水平显著降低，但NSE和BDNF水平均显著升高（P<0.05），且治疗组改善最明显（P<0.05）。结论 脑得生片联合长春西汀注射液治疗脑出血恢复期可有效改善患者神经功能损伤，促进机体神经营养状态改善，提高运动功能和降低残疾程度，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Naodesheng Tablets combined with vinpocetine in treatment of convalescence of cerebral hemorrhage.Methods Patients (92 cases) with convalescence of cerebral hemorrhage in Henan Hongli Hospital from July 2017 to August 2019 were randomly divided into control and treatment groups by double chromosphere, and each group had 46 cases. Patients in the control group were iv administered with Vinpocetine Injection, 20 mg/time added into normal saline 500 mL, and the dose can be increased to 30 mg/time if necessary, once daily. Patients in the treatment group were po administered with Naodesheng Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the NIHSS scores, FMA scores and Barthel indexes, and the serum nerve injury indexes of GFAP, S100β, MBP, NSE and BDNF in two groups before and after treatment were compared.Results After treatment, the effective rate of the control group was 80.43%, which was significantly lower than 97.83% of the treatment group (P<0.05). After treatment, the NIHSS scores were significantly decreased, while the FMA scores and Barthel indexes were significantly increased in two groups (P<0.05), and the improvement was the most obvious in the treatment group (P<0.05). After treatment, the serum levels of GFAP, S100β and MBP were significantly decreased, but the levels of NSE and BDNF were significantly increased in two groups, and the improvement in the treatment group is the more obvious (P<0.05).Conclusion Naodesheng Tablets combined with Vinpocetine Injection in treatment of cerebral hemorrhage recovery period can effectively improve the neurological function, promote the improvement of the neurotrophic status, improve motor function and reduce the degree of disability, which has a certain clinical application value.

R971