目的 探讨小儿豉翘清热颗粒联合帕拉米韦氯化钠注射液治疗儿童流行性感冒的临床疗效。方法 回顾性分析2019年9月—2020年9月漯河市第三人民医院收治的108例流行性感冒患儿的临床资料，根据住院号的奇偶性分为对照组和治疗组，每组各54例。对照组静脉滴注帕拉米韦氯化钠注射液，10 mg/kg，1次/d。治疗组在对照组基础上口服小儿豉翘清热颗粒，1～3岁患儿2～3 g/次；4～6岁3～4 g/次；7～9岁4～5 g/次；10岁以上6 g/次，3次/d。两组患儿均治疗7 d。观察两组患者临床疗效，比较治疗前后两组患者临床症状消失时间及血清超敏C反应蛋白（hs-CRP）、巨噬细胞迁移抑制因子（MIF）、高迁移率族蛋白B-1（HMGB-1）、血红素氧合酶-1（HO-1）和半胱氨酰白三烯（CYSLTS）水平。结果 治疗后，对照组总有效率为84.91%，显著低于治疗组的98.15%（P<0.05）。治疗后，治疗组患者临床症状消失时间明显早于对照组（P<0.05）。治疗后，两组患儿血清hs-CRP、MIF、HMGB1、CYSLTS水平明显降低，而HO-1水平明显升高（P<0.05）；治疗后，且治疗组这些血清学指标明显好于对照组（P<0.05）。结论 小儿豉翘清热颗粒联合帕拉米韦治疗儿童流行性感冒可显著改善临床症状，降低机体炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Xiaoer Chiqiao Qingre Granules combined with pramivir in treatment of children influenza.Methods Children (108 cases) with influenza in Luohe Third People’s Hospital from September 2019 to September 2020 were divided into control and treatment groups according to the parity number of the inpatient number, and each group had 54 cases. Children in the control group were iv administered with Peramivir and Sodium Chloride Injection, 10 mg/kg, once daily. Children in the treatment group were po administered with Xiaoer Chiqiao Qingre Granules on the basis of the control group, 2 — 3 g/time for 1 — 3 years old children, 3 — 4 g/time for 4 — 6 years old children, 4 — 5 g/time for 7 — 9 years old children, 6 g/time for more than 10 years old, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, the levels of serum hs-CRP, MIF, HMGB1, CYSLTS, and HO-1 in two groups before and after treatment were compared.Results After treatment, the effective rate of the control group was 84.91%, which was significantly lower than 98.15% in the treatment group (P<0.05). After treatment, the disappearance time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, the serum levels of hs-CRP, MIF, HMGB1, and CYSLTS in the two groups were significantly decreased, while the level of HO-1 were significantly increased (P<0.05), and these serological indexes in the treatment group were significantly better than those in the control group (P<0.05).Conclusion Xiaoer Chiqiao Qingre Granules combined with pramivir in treatment of children influenza can effectively improve the clinical symptoms, reduce the inflammatory response, which has a certain clinical application value.

R985

河南省医学科技攻关计划项目（201403258）