目的 探讨杜仲颗粒联合拉贝洛尔治疗妊娠期高血压的临床疗效。方法 选取2018年6月—2020年6月在郑州大学附属南阳市中心医院进行治疗的126例妊娠期高血压患者，根据用药差别分为对照组（63例）和治疗组（63例）。对照组口服盐酸拉贝洛尔片，0.1 g/次，2次/d，服用3 d后根据需要加量，维持剂量为0.2～0.4 g，2次/d，每日最大量2.4 g；治疗组在对照组基础上口服杜仲颗粒，5 g/次，2次/d。两组治疗7 d对比临床效果。观察两组的临床疗效，比较两组治疗前后血压、血清学指标的变化情况。结果 经治疗，治疗组总有效率是98.41%，显著高于对照组的82.54%（P<0.05）。经治疗，两组收缩压（SBP）、舒张压（DBP）均较治疗前显著下降（P<0.05）；且治疗后，治疗组SBP、DBP低于对照组（P<0.05)。经治疗，两组血清妊娠关联血浆蛋白A（PAPPA）、同型半胱氨酸（Hcy）、γ干扰素诱导蛋白16（IFI16）水平均显著下降，而胎盘生长因子（PLGF）、转甲状腺素蛋白（TTR）、人可溶性血管内皮生长因子1（sFIt-1）水平均显著增高（P<0.05)；治疗后，治疗组血清学指标改善优于对照组（P<0.05）。结论 杜仲颗粒联合拉贝洛尔治疗妊娠期高血压效果显著，可有效改善机体血清PAPPA、Hcy、IFI16、PLGF、TTR、sFIt-1水平，有着良好的临床应用价值。

Objective To investigate the clinical efficacy of Duzhong Granules combined with labetalol in treatment of gestational hypertension.Methods A total of 126 patients with gestational hypertension who were treated in Nanyang Central Hospital Affiliated to Zhengzhou University from June 2018 to June 2020 were selected and divided into control group (63 cases) and treatment group (63 cases) according to medication difference. Patients in the control group were po administered with Labetalol Hydrochloride Tablets, 0.1 g/time, twice daily. After 3 days, the dosage was increased as needed. The maintenance dosage was 0.2 — 0.4 g, twice daily, and the maximum amount was 2.4 g/d. Patients in the treatment group were po administered with Duzhong Granules on the basis of the control group, 5 g /time, twice daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the levels of blood pressure and serological indexes before and after treatment were compared between the two groups.Results After treatment, the total effective rate of the treatment group was 98.41%, which was significantly higher than that of the control group (82.54%,P<0.05). After treatment, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in two groups were significantly decreased compared with before treatment (P<0.05). After treatment, SBP and DBP in treatment group were lower than those in control group (P<0.05). After treatment, the serum levels of PAPPA, Hcy and IFI16 decreased significantly in both groups, but the levels of PLGF, TTR and SFT-1 were significantly increased (P<0.05). After treatment, the improvement of serological indexes in the treatment group was better than that in the control group (P<0.05).Conclusion Duzhong Granules combined with labetalol has a significant effect in treatment of gestational hypertension, and can effectively improve serum levels of PAPPA, Hcy, IFI16, PLGF, TTR, and sFIt-1, which has a good clinical application value.

R984

河南省科技攻关项目（201702564）