目的 探讨清浊祛毒丸联合环丙沙星治疗慢性前列腺炎的临床疗效。方法 选取2018年7月—2020年8月在郑州市第一人民医院进行治疗的106例慢性前列腺炎患者，根据住院号的奇偶数将所有患者分为对照组（53例）和治疗组（53例）。对照组口服盐酸环丙沙星片，0.25 g/次，2次/d；治疗组在对照组基础上口服清浊祛毒丸，8.0 g/次，3次/d。两组均治疗4周后进行效果比较。观察两组相关评分、尿流速、血清学指标和前列腺液相关指标的变化情况。结果 经治疗，治疗组总有效率是96.23%，显著高于对照组的81.13%（P<0.05）。经治疗，两组NIH-CPSI评分均较治疗前显著减低，而IIEF-5评分、EQS评分均显著增高（P<0.05）；治疗后，治疗组NIH-CPSI评分低于对照组，而IIEF-5评分、EQS评分高于对照组（P<0.05）。经治疗，两组患者最大尿流率（MFR）、平均尿流率（AFR）均明显增高（P<0.05）；治疗后，治疗组MFR、AFR高于对照组（P<0.05）。经治疗，两组血清白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、巨噬细胞炎性蛋白-2（MIP-2）、肿瘤坏死因子-α（TNF-α）、巨噬细胞集落刺激因子（M-CSF）均较治疗前显著下降（P<0.05）；治疗后，治疗组炎性因子水平显著低于对照组（P<0.05）。经治疗，两组前列腺液中C反应蛋白（CRP）水平显著降低，而白细胞介素-2（IL-2）、白细胞介素-4（IL-4）水平均显著升高（P<0.05）；治疗后，治疗组前列腺液中炎症指标改善优于对照组（P<0.05）。结论 清浊祛毒丸联合环丙沙星治疗慢性前列腺炎可促进患者临床症状改善，促进患者性生活质量改善，有利于降低机体炎症因子水平，提高尿流率，有一定的临床应用价值。

Objective To investigate the effect of Qingzhuo Qudu Pills combined with ciprofloxacin in treatment of chronic prostatitis.Methods A total of 106 patients with chronic prostatitis who were treated in Zhengzhou First People's Hospital from July 2018 to August 2020 were selected, and all the patients were divided into control group (53 cases) and treatment group (53 cases) according to the odds-even number of hospitalization number. Patients in the control group were po administered with Ciprofloxacin Hydrochloride Tablets, 0.25 g/time, twice daily. Patients in the treatment group were po administered with Qingzhuo Qudu Pills on the basis of the control group, 8.0 g/time, three times daily. The two groups were compared after 4 weeks of treatment. The changes of related scores, urinary flow rate, serological indexes and prostatic fluid indexes were observed in two groups.Results After treatment, the total effective rate of the treatment group was 96.23%, which was significantly higher than that of the control group (81.13%,P<0.05). After treatment, NIH-CPSI scores in both groups were significantly decreased, but IIEF-5 scores and EQS scores were significantly increased (P<0.05). After treatment, the NIH-CPSI score in the treatment group was lower than that in the control group, but the IIEF-5 score and EQS score were higher than that in the control group (P<0.05). After treatment, the maximum urine flow rate (MFR) and average urine flow rate (AFR) in two groups were significantly increased (P<0.05). After treatment, MFR and AFR in treatment group were higher than those in control group (P<0.05). After treatment, serum interleukin-1β (IL-1β), interleukin-6 (IL-6), macrophage inflammatory protein-2 (MIP-2), tumor necrosis factor-α (TNF-α), and macrophage colony stimulating factor (M-CSF) were significantly decreased in two groups compared with before treatment (P<0.05). After treatment, the level of inflammatory factors in treatment group was significantly lower than that in control group (P<0.05). After treatment, the levels of C-reactive protein (CRP) in prostatic fluid of two groups were significantly decreased, but the levels of interleukin-2 (IL-2) and interleukin-4 (IL-4) were significantly increased (P<0.05). After treatment, the improvement of inflammatory indexes in prostatic fluid in treatment group was better than that in control group (P<0.05).Conclusion Qingzhuo Qudu Pills combined with ciprofloxacin can improve the clinical symptoms of patients in treatment of chronic prostatitis, and can improve the sexual life quality of patients, help to reduce the level of inflammatory factors in the body, improve the urinary flow rate, which has a certain clinical application value.

R983

河南省医学科技攻关计划项目（2018020731）