[关键词]
[摘要]
目的 观察灯银脑通胶囊联合依达拉奉注射液治疗急性脑梗死的临床疗效。方法 选取2018年1月—2020年6月河南省精神病医院收治的93例急性脑梗死患者为研究对象,按照入院奇偶顺序法将所有患者分为对照组(46例)和治疗组(47例)。对照组静脉滴注依达拉奉注射液,将30 mg依达拉奉溶于100 mL 0.9%氯化钠注射液中,30 min内滴完,1次/d。治疗组在对照组治疗的基础上口服灯银脑通胶囊,2粒/次,3次/d。两组患者均连续治疗2周。观察两组临床疗效,比较两组的美国国立卫生院卒中量表(NIHSS)评分、Barthel指数评分量表(ADL)评分、环磷酸腺苷、血管内皮细胞生长因子(VEGF)、人纤溶酶原、β-内啡肽水平变化。结果 治疗后,治疗组的总有效率87.23%高于对照组69.57%,差异有统计学意义(P<0.05)。治疗后,两组NIHSS评分降低,ADL评分升高(P<0.05),且治疗组患者NIHSS评分低于对照组,ADL评分高于对照组(P<0.05)。治疗后,两组环磷酸腺苷、人纤溶酶原水平升高,VEGF、β-内啡肽水平下降(P<0.05),且治疗组环磷酸腺苷、人纤溶酶原水平高于对照组,VEGF、β-内啡肽水平低于对照组(P<0.05)。结论 灯银脑通胶囊联合依达拉奉注射液治疗急性脑梗死可有效减轻神经损伤,提高生活自理能力,调节环磷酸腺苷、人纤溶酶原、VEGF、β-内啡肽水平。
[Key word]
[Abstract]
Objective To observe the clinical efficacy of Dengyin Naotong Capsules combined with Edaravone Injection in treatment of acute cerebral infarction.Methods Patients (93 cases) with acute cerebral infarction in Henan Psychiatric Hospital from January 2018 to June 2020 were randomly divided into the control group (46 cases) and the treatment group (47 cases). Patients in the control group were iv administered with Edaravone Injection, 30 mg added into 0.9% sodium chloride injection 100 mL, 30 min infusion completed, once daily. Patients in the treatment group were po administered with Dengyin Naotong Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and NIHSS scores, ADL scores, the levels of cyclic adenosine monophosphate, VEGF, human plasminogen, and β-endorphin in two group were compared.Results After treatment, the total effective rate of the treatment group (87.23%) was higher than 69.57% of the control group, and the difference was statistically significant (P<0.05). After treatment, the NIHSS scores in two groups were decreased, but the ADL scores in two groups were increased (P<0.05). And the NIHSS score in the treatment group was lower than that in the control group, but the ADL score in the treatment group was higher than that in the control group After treatment, the levels of adenosine cyclophosphate and human plasminogen in two groups were increased, but the levels of VEGF and β-endorphin in two groups were decreased (P<0.05). And the levels of adenosine cyclophosphate and human plasminogen in the treatment group were higher than that of the control group, but the levels of VEGF and β-endorphin in the treatment group were lower than that of the control group (P<0.05).Conclusion Dengyin Naotong Capsules combined with Edaravone Injection in treatment of acute cerebral infarction can effectively reduce nerve injury, improve self-care ability, and regulate the levels of cyclic adenosine monophosphate, human plasminogen, VEGF, and β-endorphin.
[中图分类号]
R971
[基金项目]
河南省精神心理疾病临床医学研究中心开放课题(2020-zxkfkt-008)