目的 探讨灯盏细辛注射液联合注射用尤瑞克林治疗急性脑梗死的临床疗效。方法 选取2019年3月—2020年12月在天津市中医药研究院附属医院就诊的84例急性脑梗死患者为研究对象，按照随机数字表法将84例患者分为对照组和治疗组，每组各42例。对照组患者静脉滴注注射用尤瑞克林，0.15 PNA加入100 mL氯化钠溶液中，1次/d。治疗组患者在对照组治疗的基础上静脉滴注灯盏细辛注射液，20 mL加入250 mL生理盐水中，1次/d。两组患者连续治疗2周。考察了两组的临床疗效，比较两组患者的NIHSS评分、血清因子水平和血液流变学指标。结果 治疗后，治疗组患者的总有效率（95.24%）比对照组（80.95%）高，差异有统计学意义（P<0.05）。治疗后，两组患者的NIHSS评分显著降低，差异有统计学意义（P<0.05），且治疗组患者的NIHSS评分明显低于对照组，差异有统计学意义（P<0.05）。治疗后，两组的叶酸（FA）水平明显升高，基质金属蛋白酶-3（MMP-3）、内皮素-1（ET-1）水平明显降低，差异有统计学意义（P<0.05）；治疗后，治疗组的FA水平高于对照组，MMP-3、ET-1水平低于对照组，差异有统计学意义（P<0.05）。治疗后，两组的全血黏度、血小板黏附性、纤维蛋白原显著降低，差异有统计学意义（P<0.05）；治疗后，治疗组患者的全血黏度、血小板黏附性、纤维蛋白原低于对照组，差异有统计学意义（P<0.05）。结论 灯盏细辛注射液联合注射用尤瑞克林可提高急性脑梗死的疗效，改善血管内皮功能和血液流变学，改善神经功能，且安全性良好。

Objective To investigate the clinical efficacy of Dengzhan Xixin Injection combined with Urinary Kallidinogenase for injection in treatment of acute cerebral infarction.Methods Patients (84 cases) with acute cerebral infarction in Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital from March 2019 to December 2020 were randomly divided into control and treatment groups, and each group had 42 cases. Patients in the control group were iv administered with Urinary Kallidinogenase for injection, 0.15 PNA added into normal saline 100 mL, once daily. Patients in the treatment group were iv administered with Dengzhan Xixin Injection on the basis of the control group, 20 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and NIHSS scores, serum factors level, and hemorheology indexes in two groups were compared.Results After treatment, the total effective rate of the treatment group (95.24%) was higher than that of the control group (80.95%), and the difference was statistically significant (P<0.05). After treatment, the NIHSS scores of two groups were significantly decreased (P<0.05), and the NIHSS score of the treatment group was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the level of FA in two groups was significantly increased, but the levels of MMP-3 and ET-1 in two groups were significantly decreased, and the difference was statistically significant (P<0.05). After treatment, the level of FA in the treatment group was higher than that ole blood viscosity, platelet adhesion, and fibrinogen of the two groups were significantly decreased, and the difference was statistically significant (P<0.05). After treatment, the whole blood viscosity, platelet adhesion, and fibrinogen of the treatment group were lower than those of the control group, and the difference was statistically significant (P<0.05).Conclusion Dengzhan Xixin Injection combined with Urinary Kallidinogenase for injection can improve the curative effect of acute cerebral infarction, improve vascular endothelial function and hemorheology, improve neurological function, with good safety.

R971

天津市科技计划项目（18ZXDBSY00080）