手性是生物分子所具有的一个普遍特征，随着“反应停”事件的发生，手性在化学药领域的重要性被广泛知晓并不断掀起研究的热潮。中药中也存在着许多含有手性中心的有效成分，但由于成分复杂、含量差异大等原因，并没有引起相应的重视，而这些成分很有可能因手性的不同在药理、药动学上存在很大差异。为了对中药中手性成分有更好地研究，首先需要对对映体分离技术有更深入的了解。手性化合物的对映体分离技术主要包括非色谱法和色谱法，主要围绕这两类方法展开综述。

Chirality is a universal feature of biomolecules. With the occurrence of "Thalidomide event", the importance of chirality in the field of chemical drugs has been widely known and the research upsurge has been set off. There are many active components containing chiral centers in traditional Chinese medicine, but due to the complex components and differences of content, they have not been attracted the corresponding attention, and these components are likely to have great differences in pharmacology and pharmacokinetics due to different chirality. In order to have a better study, we need to have a deeper understanding of enantiomeric separation technology. Enantiomeric separation techniques of chiral compounds mainly include nonchromatography and chromatography. This paper will focus on these two methods.

R285

国家自然科学基金资助项目（81873194）；天津市教委科研计划项目（2019KJ078）