目的 探讨益胆片联合左氧氟沙星治疗急性胆囊炎的临床疗效。方法 选择2020年2月—2020年9月在平煤神马医疗集团总医院治疗的106例急性胆囊炎患者，根据住院顺序分成对照组（53例）和治疗组（53例）。对照组静脉滴注盐酸左氧氟沙星注射液，0.2 g加入生理盐水250 mL，2次/d。治疗组在对照组基础上口服益胆片，3片/次，3次/d。两组患者均治疗1周。观察两组患者临床疗效，比较治疗前后两组患者临床症状改善时间及血清学指标超敏C反应蛋白（hs-CRP）、巨噬细胞集落刺激因子（M-CSF）、巨噬细胞移动抑制因子（MIF）、降钙素原（PCT）和抵抗素水平。结果 经治疗，对照组总有效率为84.91%，显著低于治疗组的98.11%（P<0.05）。经治疗，治疗组在腹痛缓解时间、腹胀缓解时间、退热时间、恶心呕吐缓解时间上均优于对照组（P<0.05）。经治疗，两组患者血清hs-CRP、M-CSF、MIF、PCT、抵抗素水平均显著降低（P<0.05），治疗组最显著（P<0.05）。结论 益胆片联合左氧氟沙星治疗急性胆囊炎可有效改善患者临床症状，降低机体炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Yidan Tablets combined with levofloxacin in treatment of acute cholecystitis. Methods Patients (106 cases) with acute cholecystitis in General Hospital of Pingmei Shenma Medical Group from February 2020 to September 2020 were randomly divided into control (53 cases) and treatment (53 cases) groups based on hospitalization order. Patients in the control group were iv administered with Levofloxacin Hydrochloride Injection, 0.2 g added into normal saline 250 mL, twice daily. Patients in the treatment group were po administered with Yidan Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the improvement time of clinical symptoms, and the levels of serological indexes hs-CRP, M-CSF, MIF, PCT, and resistin in two groups before and after treatment were compared. Results After treatment, the effective rate of the control group was 84.91%, which was significantly lower than 98.11% of the treatment group (P<0.05). After treatment, abdominal pain relief time, abdominal distension relief time, antipyretic time, nausea and vomiting relief time in treatment group was shorter than that of the control group (P<0.05). After treatment, the levels of serum hs-CRP, M-CSF, MIF, PCT, and resistin in two groups were significantly decreased (P<0.05), especially in the treatment group (P<0.05). Conclusion Yidan Tablets combined with levofloxacin in treatment of acute cholecystitis can effectively improve the clinical symptoms, and reduce the body inflammatory reaction, which has a certain clinical application value.

R975