目的 探讨复方血栓通胶囊联合维胺酯胶囊治疗口腔扁平苔藓的临床疗效。方法 选取2016年7月—2019年1月在天津市口腔医院就诊的100例口腔扁平苔藓患者，按照随机数字表法将100例患者分为对照组（50例）和治疗组（50例）。对照组口服维胺酯胶囊，25 mg/次，3次/d。治疗组在对照组基础上口服复方血栓通胶囊，1.5 g/次，3次/d。两组患者连续治疗3个月。观察两组的临床疗效，比较两组的视觉模拟评分法（VAS）评分、病损面积、唾液炎性因子水平。结果 治疗后，治疗组的总有效率为94.00%，对照组的总有效率为80.00%，组间有明显差异（P<0.05）。治疗后，两组的VAS评分显著降低（P<0.05），治疗组VAS评分比对照组降低更明显（P<0.05）。治疗后，两组的病损面积明显缩小（P<0.05）；治疗后治疗组的病损面积小于对照组（P<0.05）。治疗后，两组的唾液白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白细胞介素-17（IL-17）水平明显降低（P<0.05），且治疗组的唾液IL-6、TNF-α、IL-17水平低于对照组（P<0.05）。结论 复方血栓通胶囊联合维胺酯胶囊可提高口腔扁平苔藓的疗效，减轻患者疼痛程度，缩小病损面积，降低炎症反应，安全性较高。

Objective To investigate the clinical efficacy of Compound Xueshuantong Capsules combined with Viaminate Capsules in treatment of oral lichen planus. Methods Patients (100 cases) with oral lichen planus in Department of Hexi Outpatient of Tianjin Stomatological Hospital from July 2016 to January 2019 were randomly divided into the control group (50 cases) and the treatment group (50 cases). Patients in the control group were po administered with Viaminate Capsules, 25 mg/time, three times daily. Patients in the treatment group were po administered with Compound Xueshuantong Capsules on the basis of the control group, 1.5 g/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and the vase scores, the lesion area, and the salivary inflammatory factor level in two groups were compared. Results After treatment, the total effective rate was 94.00% in the treatment group and 80.00% in the control group, with significant difference between two groups (P<0.05). After treatment, the VAS score of two groups were significantly decreased (P<0.05), and the VAS score of the treatment group was significantly lower than that of the control group (P<0.05). After treatment, the lesion area of two groups was significantly reduced (P<0.05). After treatment, the lesion area of the treatment group was lower than that of the control group (P<0.05). After treatment, the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-17 (IL-17) in saliva of two groups were significantly decreased (P<0.05), and the levels of salivary IL-6, TNF-α, and IL-17 in saliva of the treatment group were lower than those in the control group (P<0.05). Conclusion Compound Xueshuantong Capsules combined with Viaminate Capsules can improve the curative effect of oral lichen planus, reduce the degree of pain, reduce the lesion area, decrease the inflammatory reaction, with good safety.

R988.2

天津市科技计划项目（20JCQNJC00200）