目的 探讨丁细牙痛胶囊联合盐酸米诺环素软膏治疗慢性牙髓炎的临床疗效。方法 选取2019年6月—2021年1月天津市口腔医院收治的94例慢性牙髓炎患者，按照随机数字表法将所有患者分为对照组和治疗组，每组各47例。对照组患者将患齿根管内涂抹盐酸米诺环素软膏，根管封药，1次/d。治疗组在对照组基础上口服丁细牙痛胶囊，4粒/次，3次/d。两组患者连续治疗4周。考察患者的总有效率，并比较两组患者治疗后的疼痛程度和血清炎性因子水平。结果 治疗后，治疗组患者的总有效率为89.36%，对照组为72.34%，两组的总有效率有明显差异（P<0.05）。治疗后，两组的视觉模拟评分法（VAS）评分明显降低（P<0.05），且治疗组VAS评分明显低于对照组（P<0.05）。治疗后，两组的肿瘤坏死因子-α（TNF-α）、基质金属蛋白酶-9（MMP-9）、白细胞介素-8（IL-8）水平明显降低（P<0.05）；治疗后，治疗组的TNF-α、MMP-9、IL-8比对照组低（P<0.05）。结论 丁细牙痛胶囊联合盐酸米诺环素软膏治疗慢性牙髓炎的疗效确切，有助于提高疗效，减轻患者疼痛程度，降低炎症反应，且安全性良好。

Objective To investigate the clinical efficacy of Dingxi Yatong Capsules combined with Minocycline Hydrochloride Ointments in treatment of chronic pulpitis. Methods Patients (94 cases) with chronic pulpitis in Tianjin Stomatological Hospital from June 2019 to January 2021 were randomly divided into control and treatment groups, and each group had 47 cases. Patients in the control group were smeared with Minocycline Hydrochloride Ointments, and the drug was sealed in the root canal, once daily. Patients in the treatment group were po administered with Dingxi Yatong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the degree of pain and the level of serum inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group was 89.36%, and that of the control group was 72.34%, and there was significant difference between the two groups (P<0.05). After treatment, the VAS score of two groups were significantly decreased (P<0.05), and the VAS score of the treatment group was significantly lower than that of the control group (P<0.05). After treatment, the levels of TNF-α, MMP-9, and IL-8 in two groups were significantly decreased (P<0.05). After treatment, the levels of TNF-α, MMP-9, and IL-8 in the treatment group were lower than those in the control group (P<0.05). Conclusion Dingxi Yatong Capsules combined with Minocycline Hydrochloride Ointments has clinical curative effect in treatment of chronic pulpitis, can help to improve the curative effect, reduce the degree of pain, reduce the inflammatory reaction, and has good safety.

R988.2

天津市口腔医院博硕士重点青年项目（2019BSQN05）