[关键词]
[摘要]
目的 探讨正心泰颗粒联合美托洛尔治疗不稳定型心绞痛的临床疗效。方法 选取2019年1月—2020年1月在阜外华中心血管病医院心血管外科住院的80例不稳定型心绞痛患者,随机分为对照组和治疗组,每组各40例。对照组口服酒石酸美托洛尔片,1片/次,2次/d。治疗组患者在对照组的基础上口服正心泰颗粒,1袋/次,3次/d。两组均连续治疗14 d。观察两组患者的临床疗效,同时比较两组患者治疗前后心率、心绞痛每日发作频率、发作持续时间指标、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、心肌肌钙蛋白(cTnI)水平,比较两组患者治疗前后白细胞介素6(IL-6)、肿瘤坏死因子(TNF-α)、血同型半胱氨酸(HCY)、超敏C反应蛋白(hs-CRP)水平。结果 治疗后,治疗组总有效率是95.00%,显著高于对照组的72.50%(P<0.05)。治疗后,两组患者心率、心绞痛每日发作频率、发作持续时间均显著低于同组治疗前(P<0.05);治疗后,治疗组这些临床症状发作情况优于对照组(P<0.05)。治疗后,两组患者CK-MB、LDH、CK、cTnI均较治疗前显著降低(P<0.05);治疗后,治疗组心肌酶水平显著低于对照组(P<0.05)。治疗后,两组患者IL-6、TNF-α、HCY、hs-CRP水平均显著降低(P<0.05);治疗后,治疗组血清炎性因子水平低于对照组(P<0.05)。结论 正心泰颗粒联合美托洛尔治疗不稳定型心绞痛患者临床疗效显著提升,并能改善心肌缺血状态,降低炎性因子水平,在临床上值得借鉴与推广使用。
[Key word]
[Abstract]
Objective To investigate the efficacy of Zhengxintai Granules combined with metoprolol in treatment of unstable angina pectoris. Methods A total of 80 patients with unstable angina pectoris who were hospitalized in the Department of Cardiovascular Surgery of Fuwai Central China Cardiovascular Hospital from January 2019 to January 2020 were randomly divided into control group and treatment group, with 40 patients in each group. Patients in the control group were po administered with Metoprolol Tartrate Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Zhengxintai Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and heart rate, daily frequency of attack, duration of angina, creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), creatine kinase (CK), and myocardial troponin (cTnI) levels in two groups before and after treatment were compared. The levels of interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), blood homocysteine (HCY), hypersensitive C-reactive protein (hs CRP) in two groups were compared. Results After treatment, the total effective rate of treatment group was 95.00%, which was significantly higher than that of control group (72.50%, P<0.05). After treatment, heart rate, daily attack frequency and duration of angina pectoris in two groups were significantly lower than before treatment (P<0.05). After treatment, the onset of these clinical symptoms in the treatment group was better than that in the control group (P<0.05). After treatment, the levels of CK-MB, LDH, CK, and cTnI in two groups were significantly decreased compared with before treatment (P<0.05). After treatment, the level of myocardial enzyme in treatment group was significantly lower than that in control group (P<0.05). After treatment, the levels of IL-6, TNF-α, Hcy, and hs-CRP in two groups were significantly decreased (P<0.05). After treatment, the level of serum inflammatory factors in treatment group was lower than that in control group (P<0.05). Conclusion Zhengxintai Granules combined with metoprolol has significantly improved clinical efficacy in treatment of unstable angina pectoris, and can improve myocardial ischemia, and can reduce the level of inflammatory factors, which is worthy of reference and promotion in clinical use.
[中图分类号]
R972
[基金项目]