[关键词]
[摘要]
目的 探讨银丹心脑通软胶囊联合瑞舒伐他汀钙片治疗经皮冠脉介入术(PCI)后急性心肌梗死的临床疗效。方法 选取2017年1月—2020年1月鹤壁市人民医院收治的80例急性心肌梗死患者,根据信封法分为对照组和治疗组,每组各40例。对照组口服瑞舒伐他汀钙片,20 mg/次,1次/d。治疗组患者在对照组治疗的基础上口服银丹心脑通软胶囊,3粒/次,3次/d。两组患者均连续治疗14 d。观察两组患者临床疗效,比较两组心功能、血脂情况。结果 治疗后,对照组总有效率为70.00%,治疗组总有效率为90.00%,治疗组较对照组高(P<0.05)。治疗后,两组左心室射血分数(LVEF)升高,左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)下降(P<0.05),并且治疗后治疗组LVEF高于对照组,LVESD、LVEDD低于对照组(P<0.05)。治疗后,两组总胆固醇(TC)、低密度脂蛋白(LDL)、三酰甘油(TG)水平较治疗前下降,高密度脂蛋白(HDL)水平较治疗前升高(P<0.05),且治疗组TC、LDL、TG水平低于对照组,HDL水平高于对照组(P<0.05)。治疗后,两组梗死面积、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)较治疗前下降(P<0.05),且治疗组梗死面积、CK-MB、LDH低于对照组(P<0.05)。结论 银丹心脑通软胶囊联合瑞舒伐他汀钙片可改善经皮冠脉介入术后急性心肌梗死患者的心功能、血脂、心肌酶谱、梗死面积,药物临床疗效值得肯定。
[Key word]
[Abstract]
Objective To investigate the effect of Yindan Xinnaotong Soft Capsules combined with Rosuvastatin Calcium Tablets in treatment of acute myocardial infarction after percutaneous coronary intervention. Methods Patients (80 cases) with acute myocardial infarction after percutaneous coronary intervention in the People’s Hospital of Hebi from January 2017 to January 2020 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were po administered with Rosuvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the treatment group were po administered with Yindan Xinnaotong Soft Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and heart function and blood lipid were compared between two groups. Results After treatment, the total effective rate of the control group was 70.00%, and that of the treatment group was 90.00%, which was higher than that of the control group (P<0.05). After treatment, the LVEF in two groups were increased, but the LVESD and LVEDD in two groups were decreased (P<0.05). And the LVEF in the treatment group was higher than that in the control group, while the LVESD and LVEDD in the treatment group were lower than those in the control group (P<0.05). After treatment, the levels of TC, LDL, and TG in two groups were decreased, while the levels of HDL in two groups were increased (P<0.05). The levels of TC, LDL, and TG in the treatment group were lower than those in the control group, but the level of HDL in the treatment group was higher than that in the control group (P<0.05). After treatment, the infarct size, CK-MB, and LDH of two groups were decreased (P<0.05), and the infarct size, CK-MB, and LDH of the treatment group were lower than those of the control group (P<0.05). Conclusion Yindan Xinnaotong Soft Capsules combined with Rosuvastatin Calcium Tablets in treatment of acute myocardial infarction after percutaneous coronary intervention can improve the cardiac function, blood lipid, myocardial enzyme spectrum and infarct size, and the clinical efficacy of the drug is worthy of affirmation.
[中图分类号]
R972
[基金项目]
河南省医学科技攻关计划项目(201603117)