[关键词]
[摘要]
目的 探讨大黄利胆胶囊联合左氧氟沙星治疗急性胆囊炎的临床研究。方法 选取2019年3月-2020年3月在南阳市中心医院治疗的急性胆囊炎患者122例为研究对象,随机分为对照组(61例)和治疗组(61例)。对照组患者口服左氧氟沙星片,0.1 g/次,2~3次/d;治疗组在对照组的基础上口服大黄利胆胶囊,2粒/次,2~3次/d。两组患者均治疗14 d。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状,血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(1L-6)和1L-8水平及血液白细胞计数(WBC)、总胆红素(TBIL)和淀粉酶(AMY)水平。结果 治疗后,对照组和治疗组临床总有效率分别为78.69%和93.44%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组患者临床症状恢复好转时间均显著早于对照组(P<0.05)。治疗后,两组患者CRP、TNF-α、1L-6、1L-8、WBC、TBIL和AMY水平均明显降低(P<0.05);且治疗组显著低于对照组(P<0.05)。结论 黄利胆胶囊联合左氧氟沙星提高了临床效果,缩短临床症状的缓解时间,改善炎症指标,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To explore the clinical efficacy of Dahuang Lidan Capsules combined with levofloxacin in treatment of acute cholecystitis. Methods Patients (122 cases) with acute cholecystitis in Nanyang Central Hospital from March 2019 to March 2020 were randomly divided into control (61 cases) and treatment (61 cases) groups. Patients in the control group were po administered with Levofloxacin Tablets, 0.1 g/time,2-3 time/d. Patients in the treatment group were po administered with Dahuang Lidan Capsules on the basis of the control group, 2 grains/time,2-3 time/d. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom, the levels of CRP, TNF-α, 1L-6, 1L-8, WBC, TBIL, and AMY in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 78.69% and 93.44% respectively, and there were differences between two groups (P<0.05). After treatment, the recovery time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, the levels of CRP, TNF-α, 1L-6, 1L-8, WBC, TBIL, and AMY in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Dahuang Lidan Capsules combined with levofloxacin in treatment of acute cholecystitis is effect, and can shorten the remission time of clinical symptoms, improve the inflammation indexes, which has a certain clinical application value.
[中图分类号]
R978
[基金项目]
河南省高等学校青年骨干教师资助计划项目(2014GGJS-187)