Objective To study the effect of Xiaoer Jiegan Granules combined with Cefuroxime Axetil Dispersible Tablets in treatment of acute upper respiratory tract infection in children.
Methods Children (180 cases) with acute upper respiratory tract infection in the First Affiliated Hospital of Henan University of Science and Technology from February 2018 to February 2020 were randomly divided into control and treatment groups, and each group had 90 cases. Patients in the control group were
po administered with Cefuroxime Axetil Dispersible Tablets, 0.125 g/time, twice daily. Patients in the treatment group were
po administered with Xiaoer Jiegan Granules on the basis of the control group, 1-3 year old, 0.5 bag/time, 4-6 year old, 1 bag/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and clinical symptoms remission time, myocardial enzyme index, serum inflammatory factors in two groups were compared.
Results After treatment, the total effective rate of the treatment group was 94.44%, which was significantly higher than 80.00% of the control group (
P < 0.05). After treatment, the disappeared time of fever, throat swelling, cough, nasal congestion and runny nose in the treatment group were significantly shorter than those in the control group (
P < 0.05). After treatment, the serum levels of α-HBDH and CK-MB in two groups were significantly decreased (
P < 0.05), and the levels of serum α-HBDH and CK-MB in the treatment group were significantly lower than those in the control group (
P < 0.05). After treatment, the serum levels of hs-CRP, IL-6, TNF-α, and PCT in two groups were significantly decreased (
P < 0.05), and the serum levels of hs-CRP, IL-6, TNF-α, and PCT in the treatment group were significantly lower than those in the control group (
P < 0.05).
Conclusion Xiaoer Jiegan Granules combined with Cefuroxime Axetil Dispersible Tablets has good effect in treatment of acute upper respiratory tract infection in children, can improve the clinical symptoms, reduce the serum levels of myocardial enzymes and inflammatory factors.