目的 探讨小儿双清颗粒联合头孢西丁治疗小儿急性上呼吸道感染的临床疗效。方法 选取2018年8月-2019年8月在天津市泰达医院就诊的急性上呼吸道感染患儿150例，根据用药的差别分为对照组（75例）和治疗组（75例）。对照组静脉滴注注射用头孢西丁钠，13.3~26.7 mg/kg加入生理盐水100 mL；治疗组在对照组基础上口服小儿双清颗粒，1~3岁，2~3 g/次，4~6岁，3~4 g/次，>6岁，4~5 g/次，3次/d。两组患儿均治疗7 d。观察两组患者临床疗效，同时比较治疗前后两组患儿临床症状消失时间，及血清超敏C反应蛋白（hs-CRP）、降钙素原（PCT）、白细胞介素-6（IL-6）、IL-1β、肿瘤坏死因子-α（TNF-α）水平。结果 治疗后，对照组和治疗组临床有效率分别为82.67%和97.33%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组患者症状消失时间明显早于对照组（P<0.05）。治疗后，两组患者血清hs-CRP、PCT、IL-6、IL-1β、TNF-α水平均明显降低（P<0.05），且治疗组患者明显低于对照组（P<0.05）。结论 小儿双清颗粒联合头孢西丁钠治疗小儿急性上呼吸道感染，能显著改善临床症状，降低机体炎症因子表达，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Xiaoer Shuangqing Granules combined with cefoxitin in treatment of acute upper respiratory tract infection in children. Methods Children (65 cases) with acute upper respiratory tract infection in Tianjin TEDA Hospital from August 2018 to August 2019 were randomly divided into control (75 cases) and treatment (75 cases) groups. Children in the control group were iv administered with Cefoxitin Sodium for injection, 13.3-26.7 mg/kg added into normal saline 100 mL. Children in the treatment group were po administered with Xiaoer Shuangqing Granules on the basis of the control group, 2-3 g/time for 1-3 years old, 3-4 g/time for 4-6 years old, 4-5 g/time for more than 6 years old, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, and the serum levels of hs-CRP, PCT, IL-6, IL-1β and TNF-α in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 82.67% and 97.33% respectively, and there were differences between two groups (P < 0.05). After treatment, the disappearance time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the serum levels of hs-CRP, PCT, IL-6, IL-1β and TNF-α in two groups were significantly decreased (P < 0.05), and these serological indexes levels in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Xiaoer Shuangqing Granules combined with cefoxitin in treatment of acute upper respiratory tract infection in children can significantly improve the clinical symptoms, decrease the expression of inflammatory factors, which has a certain clinical application value.

R974