目的 回顾性调查分析2018-2019年长沙市第三医院介入治疗手术围手术期抗菌药物预防使用的合理性，了解其使用情况及存在问题，以进一步规范介入手术围手术期抗菌药物合理使用。方法 采用回顾性分析方法，对长沙市第三医院2018-2019年介入手术病例进行抗菌药物使用情况分析。结果 1 967例患者中，37例预防使用抗菌药物，预防使用率为1.88%，总体合理率为99.44%。诊断性介入手术预防使用率为零，符合要求，治疗性介入手术中存在11例不合理，2例为无适应症用药，4例为药物选择不适宜，6例预防使用疗程偏长（1例同时存在两种不合理）。结论 2018-2019年长沙市第三医院介入手术患者预防抗菌药物使用情况比较合理，进一步加强医院专项整治和临床药师干预，提高抗菌药物预防使用合理性。

Objective To investigate the rationality of the prophylactic antibiotics in intervention therapy in the Third Hospital of Changsha City from 2018 to 2019 retrospectively, and analyze the existing problems, to further standardize the rational use of antibiotics. Methods The retrospective analysis was used to investigate the perioperative antibiotics use in the patients with intervention surgery in the Third Hospital of Changsha City from 2018 to 2019. Results Of the 1 967 patients, 37 cases used prophylactic antibiotics with the use rate of 1.88%, and the overall reasonable rate was 99.44%. The use rate of diagnostic interventional surgery was zero, which meets the requirements. There were 11 cases of treatment intervention unreasonable, 2 cases of non-indications, and 4 cases of unsuitable drug selection, and 6 cases of prolonged treatment(1 case of both). Conclusion The use of perioperative prophylactic antibiotics in patients undergoing intervention surgery is reasonable in the Third Hospital of Changsha City from 2018 to 2019, and further strengthen the special rectification of hospitals and clinical pharmacist intervention to improve the rationality of antibiotics use.

R978.1

湖南省科技计划项目（2016SK4008）